Siena vs Indiana Prediction 12/22/2025 Today’s College Basketball Picks

In this article we will formulate a Siena vs Indiana prediction for this College Basketball game on Monday, December 22nd at Assembly Hall in Bloomington, Indiana. Let’s take a look at the prediction for this College Basketball matchup.

Siena Saints Betting Preview

The Siena Saints are 9-3 this season after they lost to Vermont by a score of 83-69 in their last game. Siena trailed 41-27 at halftime, but did score 42 points in the second half in the loss. The Saints shot 39% from the field, 29% on three pointers, and 85% on free throws in the game. Gavin Doty led Siena with 18 points and 11 rebounds, while Brendan Coyle added 15 points and five rebounds in the loss. 

Prior to that game, Siena defeated Canisius by a score of 74-52 and Niagara by a score of 83-54. The Saints have scored 70.3 points per game with 34.5 rebounds and 13.2 assists per game, while they have allowed 63.2 points against per game this season. Gavin Doty is averaging 14.8 points and 6.3 rebounds per game, while Justice Shoats is averaging 12.7 points and 5.3 assists per game for the Saints. Siena is shooting 45.9% from the field, 71.1% on free throws, and 29.0% on three pointers this season. 

Indiana Hoosiers Betting Preview

The Indiana Hoosiers are 9-3 this year after they defeated Chicago State by a score of 78-58 in their last game. Indiana led 52-29 at halftime, but they were outscored 29-26 in the second half in the win. The Hoosiers shot 42% from the field, 33% on three pointers, and 61% on free throws in the game. Lamar Wilkerson led Indiana with 21 points and six assists, while Reed Bailey added 17 points and eight rebounds in the win. 

Prior to that game, Indiana lost to Kentucky by a score of 72-60, but did beat Penn State by a score of 113-72 before that. The Hoosiers have scored 85.0 points per game with 36.9 rebounds and 19.7 assists per game, while they have allowed 66.6 points against per game this season. Lamar Wilkerson is averaging 18.7 points and 2.7 assists per game, Tucker DeVries is averaging 16.3 points and 4.9 rebounds per game for the Hoosiers. Indiana is shooting 48.6% from the field, 76.2% on free throws, and 36.0% on three pointers this year. 

Why the Indiana Hoosiers will win

• Indiana has won each of its last 18 games against non-Conference opponents at Simon Skjodt Assembly Hall.
• Siena has lost three of its last four games when playing with a rest advantage.

Why the Siena Saints will win

• Siena has won seven of its last eight games against non-AP-ranked opponents.

Total Points Facts

• Ten of Siena’s last 11 games against non-AP-ranked opponents have produced a total of 142 or fewer points.
• Three of Indiana’s last four games against non-AP-ranked opponents have produced a total of 137 or fewer points.

Siena vs Indiana Prediction 

Siena comes into this contest after having their winning streak snapped last time out and they will be on the road, where they are 3-2. The Saints are shooting 46% from the field and they have allowed 60 points or fewer in four of their last five. Indiana has lost three of their last five games, but they are 8-0 at home. The Hoosiers are shooting 49% from the field and while they have struggled against the good teams on their schedule, they have done a good job dominating the lesser teams. Take Indiana to win big here.

David Racey's Pick: Indiana -23.5