Pennsylvania vs Villanova Prediction 12/6/2025 Today’s College Basketball Picks

The Penn Quakers and the Villanova Wildcats meet Saturday in college basketball action from the XFinity Mobile Arena. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Penn Quakers vs. Villanova Wildcats prediction.

Penn Quakers Recap

The Penn Quakers come into this game looking to bounce back from a 77-60 loss at the hands of Hofstra last time out to sit at 5-3 this season. After this game, Penn will head home for a game against Lafayette.

Quakers Have Four-Game Win Streak Snapped

Ethan Roberts has 20.2 PPG with 4.1 RPG and 2.8 APG while Michael Zanoni has 10.6 PPG as well this season. TJ Power has 15.6 PPG with 7.9 RPG and 2.6 APG to lead Penn in rebounding and to cap off the group of double-digit scorers for Penn so far this season. Dalton Scantlebury has 8.1 PPG with 5.5 RPG and Cam Thrower has 7 PPG. Augustus Gerhart has 5.9 PPG and 6.8 RPG and AJ Levine has a team-high 3.5 APG to lead the Quakers in assists up to this point in the year. As a team, Penn is averaging 81.9 PPG on 45.2% shooting from the field, 39.8% from three and 71.8% from the foul line this season.

Villanova Wildcats Recap

The Villanova Wildcats come into this game looking to build on their 74-56 win over Temple last time out to sit at 6-1 this season. After this game, Villanova will head on the road for a game against Michigan.

Wildcats Win 6 Straight

Bryce Lindsay leads the Wildcats in scoring with 18.1 PPG with 2.7 RPG and 2.6 APG while Acaden Lewis has 13.3 PPG with 3.3 RPG and 5.6 APG to lead the Wildcats in assists. Matt Hodge has 11.1 PPG with 4.1 RPG and Duke Brennan has 10.8 PPG with a team-high 13.3 RPG to lead the Wildcats in rebounding by averaging a double-double per game. Tyler Perkins has 12.1 PPG and 5 RPG to cap off the group of double-digit scorers for Villanova up to this point in the year. Devin Askew also has 7.7 PPG as well this season. As a team, Villanova is averaging 82 PPG on 47.5% shooting from the field, 36.4% from three and 69.2% from the foul line this season. 

Penn Quakers @ Villanova Wildcats Betting Trends: December 6, 2025

Why the Villanova Wildcats will win

• Villanova has won each of its last 10 home night games against non-Conference opponents.
• Penn has lost seven of its last eight road games against non-Conference opponents.
• Villanova has won the first half in each of its last 10 home night games against non-Conference opponents.

Why the Penn Quakers will win

• Penn has won four of its last five games.
• Penn has won the first half in three of its last four games.

Total Points Facts

• Each of Penn’s last nine night games have produced a total of 152+ points.
• Eighteen of Villanova’s last 19 games against non-AP-ranked opponents at Xfinity Mobile Arena have produced a total of 148 or fewer points.

Matchup/League Facts

• Villanova ranks T3rd among Division 1 teams for opponent blocks per game this season (1.7).
• Villanova ranks 4th among Division 1 teams for opponent rebounds per game this season (28.3).
• Penn ranks 21st among Division 1 teams for three-point percentage this season (39.8%).
• Penn ranks 31st among Division 1 teams for free throw attempts per game this season (26.6).

Penn Quakers vs. Villanova Wildcats Prediction

I’m on Penn and the points here. I get that Villanova demolished Penn last time these two teams faced off, but this is the championship of the Big 5 tournament and all the teams involved take this competition seriously. Penn isn’t just happy to be here, they want to win this title and I’m sure exact some revenge after last year’s debacle. I also wonder if Villanova has some form of distraction with Michigan on deck. I think Penn will have Villanova’s focus at the end of the day, but this is too many points. Give me Penn.

Chris Ruffolo's Pick: Penn +19.5