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Old Dominion vs Southern Mississippi Prediction 2/21/2026 Today’s College Basketball Picks

Nov 9, 2025; Columbia, South Carolina, USA; South Carolina Gamecocks forward Myles Stute (10) blocks the shot of Southern Mississippi Golden Eagles forward Tylik Weeks (4) in the second half at Colonial Life Arena. Mandatory Credit: Jeff Blake-Imagn Images

Nov 9, 2025; Columbia, South Carolina, USA; South Carolina Gamecocks forward Myles Stute (10) blocks the shot of Southern Mississippi Golden Eagles forward Tylik Weeks (4) in the second half at Colonial Life Arena. Mandatory Credit: Jeff Blake-Imagn Images

MATCHUP Old Dominion Monarchs Southern Mississippi Golden Eagles
Team Records 10-18 12-12
Spread +5.5 -115 -5.5 -105
Moneyline +180 -218
Total Over 147.5 (-112) Under 147.5 (-108)
Where Reed Green Coliseum, Hattiesburg, MS
When Saturday, February 21, 2026
Time 03:00 PM EST
TV ESPN+
The Old Dominion Monarchs and Southern Miss Golden Eagles meet Saturday in college basketball action at the Reed Green Coliseum. Here’s an Old Dominion vs. Southern Mississippi prediction. This article will include an Old Dominion vs. Southern Mississippi pick.

Old Dominion Monarchs Betting Preview


The Old Dominion Monarchs beat Georgia State and Louisiana, and they play Marshall next. Old Dominion has split its last 10 games.

The Old Dominion Monarchs are averaging 77.5 points on 43.9 percent shooting and allowing 79.5 points on 43.6 percent shooting. KC Shaw is averaging 17 points and 4.2 rebounds, while Jordan Battle is averaging 14 points and 4.8 rebounds. LJ Thomas is the third double-digit scorer, and Robert Davis Jr. is dishing 1.5 assists. The Old Dominion Monarchs are shooting 33.9 percent from beyond the arc and 72.3 percent from the free throw line. The Old Dominion Monarchs are allowing 31.8 percent shooting from deep and are grabbing 32.8 rebounds per game.

Southern Miss Golden Eagles Betting Preview


The Southern Miss Golden Eagles lost to South Alabama, beat Troy, and play Arkansas State next. Southern Miss has lost 7 of its last 10 games.

The Southern Miss Golden Eagles are averaging 73.4 points on 44.4 percent shooting and allowing 73.3 points on 43.5 percent shooting. Tylik Weeks is averaging 18.4 points and 5.9 rebounds, while Isaac Taveras is averaging 15.1 points and 2.2 assists. Djahi Binet is the third double-digit scorer, and Dylan Brumfield is dishing 2.9 assists. The Southern Miss Golden Eagles are shooting 29.2 percent from beyond the arc and 74 percent from the free throw line. The Southern Miss Golden Eagles are allowing 35.2 percent shooting from deep and are grabbing 33.3 rebounds per game.

Why the Southern Miss Golden Eagles will win

Why the Old Dominion Monarchs will win

Total Points Facts

Matchup/League Facts

Old Dominion vs Southern Mississippi Prediction


Southern Mississippi should be favored at home and is probably the better team, but I’m just not impressed. Southern Mississippi has lost 7 of its last 10 games, and a lot of those games were winnable. Old Dominion hasn’t had a great season in its own right, but it has won 3 of its last 4 games, and that includes an upset over Ohio. Old Dominion also nearly beat Marshall. Old Dominion could easily be 4-0 SU and ATS in its last 4 games. I’ll take a stab with the free buckets.

Randy Chambers's Pick: Old Dominion +4.5

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