| MATCHUP | Northwestern Wildcats | DePaul Blue Demons |
|---|---|---|
| Team Records | 3-0 | 2-1 |
| Spread | -6.5 -110 | +6.5 -110 |
| Moneyline | -298 | +240 |
| Total | Over 138.5 (-115) | Under 138.5 (-105) |
| Where | Wintrust Arena, Chicago, IL | |
| When | Friday, November 14, 2025 | |
| Time | 08:30 PM EST | |
| TV | truTV | |
The Northwestern Wildcats and the DePaul Blue Demons meet Friday in college basketball action from Wintrust Arena. Here’s a Northwestern vs DePaul prediction. We will look at this from a betting perspective and determine the best Northwestern vs DePaul pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.
Northwestern Wildcats Betting Preview
Northwestern opened their 2025-26 season with a matchup versus Mercyhurst at home on Monday. In that one Northwestern posted 36 points in the first half and 34 more in the second on the way to a 70-47 blowout win. Top performer Arrinten Page doubled up on 18 points with 12 rebounds, and Nick Martinelli had 17 points with five boards in the victory. Also in double-figures was KJ Windham with 11 points and seven rebounds in 21 minutes of work on the floor in the blowout. In game two Northwestern took on Boston U last Friday. The Wildcats were up 45-26 by the end of the first half then cruised on a 31-26 run for a 76-52 win in the end. Tops in scoring was Nick Martinelli with 20 points and nine rebounds. Jayden Reid added 17 points with eight assists and one rebound in 27 minutes of action during the winning effort.
Matched up against Cleveland State on Monday it was more of the same for the Wildcats. Northwestern was ahead 53-28 going into the second half then scored 57 more points in a 110-63 blowout victory this time. Nick Martinelli was tops again with 21 points and seven boards while Arrinten Page chipped in 17 points, nine rebounds and three assists in 24 minutes of work. Justin Mullins and Max Green each had 16 points as well, combining for six boards.
DePaul Blue Demons Betting Preview
Over on the DePaul side, they’ve got three games in the books as well. The Demons kicked things off last Monday versus Chicago State, putting up a 46-21 edge in the first half. DePaul scored 46 more points in the second half in a 92-62 win in the end. Layden Blocker posted 16 points with four assists while NJ Benson doubled up on 16 points and 10 rebounds. In game two the Blue Demons played Stonehill. DePaul was up 37-24 by halftime and won 72-64 despite a five-point deficit from there. Tops in scoring was CJ Gunn with 28 points and six boards. NJ Benson was the only other team player in double-figures, putting up 16 points and 10 rebounds in 31 minutes for another double-double on his card.
In game three on Tuesday versus a tricky Buffalo team, DePaul got their first loss. The Demons were down 36-18 after one half and limped to a 66-53 defeat in the end. NJ Benson was the only player on the team to finish in double-digits this time with 11 points and eight boards. Brandon Maclin got close though, putting up nine points and five rebounds.
Northwestern Wildcats @ DePaul Blue Demons Betting Trends: November 14, 2025
Why the DePaul Blue Demons will win
- DePaul has won 12 of its last 13 games against non-Conference opponents at Wintrust Arena.
- Northwestern has lost three of its last four night games following a home win.
Why the Northwestern Wildcats will win
- Northwestern has won each of its last seven games against non-Conference opponents.
- DePaul has lost 15 of its last 17 games following a home loss.
Northwestern vs DePaul Prediction
I’ll stick with Northwestern. The Wildcats have been on a nice run through three games so far and they’re coming off another dominant effort versus Cleveland State. In that one Northwestern shot 60.3 percent from the field with 52.4 percent (11-of-21) from outside. The 40-25 rebounding edge, 26 team assists and 52-26 advantage in the paint helped quite a bit, as did the acceptable seven turnovers.
As for DePaul, they put up just 33.3 percent shooting in the loss to Buffalo and missed half their free throws (10-of-20). The Demons had 18 turnovers and scored just 16 points in the paint. Northwestern should have the advantage here, even on the road.