| MATCHUP | Niagara Purple Eagles | Duke Blue Devils |
|---|---|---|
| Team Records | 2-2 | 5-0 |
| Where | Cameron Indoor Stadium, Durham, NC | |
| When | Friday, November 21, 2025 | |
| Time | 07:00 PM EST | |
| TV | ACC Network | |
The Niagara Purple Eagles and the Duke Blue Devils meet Friday in college basketball action from Cameron Indoor Stadium. Here’s a Niagara vs Duke prediction. We will look at this from a betting perspective and determine the best Niagara vs Duke pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.
Niagara Purple Eagles Betting Preview
The Purple Eagles have four games in the bag so far this year, with a .500 record to show for it. First came an 83-63 loss to Duquesne in the opener. Leading scorer Reggie Prudhomme put up 16 points in 28 minutes during the losing effort and Justin Page added 14 points. In game two versus Binghamton, Niagara got their first win of the year 67-59 despite just 22 first-half points. The Eagles’ Trenton Walters led the way this time on 23 points. As for game three, that was another win. This one was 68-57 over Delaware State. Justin Hawkins was the high man this time with 13 points, and both Page and Josiah Sabino notched 12 points apiece.
In their most recent outing Monday versus LeMoyne, Niagara was outscored 42-36 in the second half during a 74-68 loss. Vice Zanki was tops on the team with 16 points in 25 minutes and Reggie Prudhomme had 15 points and eight rebounds. Justin Hawkins chimed in with 10 points, five rebounds and four assists in the losing effort as well.
Duke Blue Devils Betting Preview
Over on the Duke side, they played Texas in their opener. After halftime, the Blue Devils got going with a 43-27 stretch in a 75-60 comeback win. Tops on the team was Isaiah Evans with 23 points in 33 minutes. Cameron Boozer added a double-double on 15 points, 13 rebounds and two assists as well. In game two against Western Carolina, the Blue Devils posted a 45-21 advantage then a 50-33 run that gave them a 95-54 victory. Leading the way was Cameron Boozer with 25 points, eight boards and five assists in 23 minutes. Cayden Boozer had 14 points, seven rebounds and five assists. Patrick Ngongba put up 10 points with seven rebounds. In game three versus Army, Duke took a decisive 114-59 victory. Dame Sarr led this time on 19 points and three rebounds in 20 minutes on the court. As for game four against Indiana State last week, Duke kept it goin. After a 51-32 first-half run the Blue Devils hit a 49-30 stretch for a 100-62 victory. Cameron Boozer doubled up on 35 points and 12 rebounds while Caleb Foster had 14 options with four rebounds and two assists. Dame Sarr was also in double-digits with 10 points in 18 minutes.
On Tuesday versus Kansas, Duke scored 41 points in the first half on the way to a nice 78-66 victory. Leading the charge with a double-double was Cameron Boozer on 18 points, 10 rebounds and five assists. Isaiah Evans added 16 points with four boards and three assists.
Niagara Purple Eagles @ Duke Blue Devils Betting Trends: November 21, 2025
Why the Duke Blue Devils will win
- Duke has won each of its last 19 games at Cameron Indoor Stadium.
- Niagara has lost each of its last five road night games against non-Conference opponents.
- Niagara has lost the first half in three of its last four games against the Atlantic Coast Conference.
Niagara vs Duke Prediction
I might take a stab on Niagara here. Probably not touching it, though. The Eagles didn’t look great in their last outing versus a LeMoyne team they probably should have beaten. Niagara shot just 40 percent from the field and got out-rebounded 33-29. The Dolphins were great at the line though (20-of-22) so credit where credit is due. No one is expecting Niagara to stay anywhere close to Duke in this one, but if the Eagles can get a good push early—and stay consistent the whole game with high-percentage shots—they may eke in there.