Loyola Chicago vs St. Louis Prediction 3/4/2026 Today’s College Basketball Picks

The Loyola Chicago Ramblers and the Saint Louis Billikens meet Wednesday in college basketball action from the Moody Coliseum. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Loyola Chicago Ramblers vs. Saint Louis Billikens prediction.

Loyola Chicago Ramblers Recap

The Loyola Chicago Ramblers come into this game looking to add on to their 69-66 win over Richmond last time out to sit at 7-22 this season. After this game, Loyola Chicago will head home for a game against George Washington.

Ramblers Snap Four-Game Slide

Miles Rubin leads Loyola Chicago in scoring and rebounding with 11.1 PPG and 7.2 RPG while Justin Moore has 10.9 PPG with 2.2 RPG and a team-high 3.8 APG to lead the Ramblers in assists. Xavier Amos has 10.6 PPG with 3.9 RPG to cap off the trio of double-digit scorers for Loyola Chicago so far this season. Kayde Dotson has 9.7 PPG with 2.5 RPG and Deywilk Tavarez has 9 PPG. As a team, Loyola Chicago is averaging 66.8 PPG on 41.9% shooting from the field, 30.9% from three and 66.8% from the foul line this season. 

Saint Louis Billikens Recap

The Saint Louis Billikens come into this game looking to add on to their 91-76 win over Duquesne last time out to sit at 26-3 this season. After this game, Saint Louis will head on the road for a game against George Mason.

Billikens Alternate Wins & Losses In 5 Straight

Robbie Avila leads the Billikens in scoring with 13 PPG along with a team-high 4.2 APG and 4.5 RPG while Dion Brown has 11 PPG with a team-high 5.7 RPG to lead the Billikens in rebounding. Amari McCottry has 10.2 PPG with 5.3 RPG and 2.9 APG. Trey Green has 11.4 PPG with 2.9 RPG and Quentin Jones has 10 PPG with 4.1 RPG and 3 APG to cap off the scoring in double figures for the Billikens this season. Kellen Thames has 9.9 PPG with 5 RPG and Ishan Sharma has 9.3 PPG with 2.7 RPG. As a team, Saint Louis is averaging 89.2 PPG on 51.4% shooting from the field, 40.9% from three and 73.8% from the foul line this season.

Loyola Ramblers @ Saint Louis Billikens Betting Trends: March 4, 2026

Why the Saint Louis Billikens will win

• Saint Louis has won each of its last 21 games at Chaifetz Arena.
• Loyola (IL) has lost each of its last seven road games.
• Loyola (IL) has lost the first half in each of its last six games against AP-ranked opponents.

Why the Loyola Ramblers will win

• Loyola (IL) has won three of its last four night games against Saint Louis.
• Saint Louis has lost the first half in each of its last four games.

Total Points Facts

• Each of Loyola (IL)’s last 22 games against AP-ranked opponents have produced a total of 153 or fewer points.
• Fourteen of Saint Louis’ last 15 Wednesday night home games against Conference opponents have produced a total of 154 or fewer points.

Matchup/League Facts

• Saint Louis ranks 1st among Division 1 teams for opponent field goal percentage this season (36.9%).
• Saint Louis has recorded the equal-longest winning streak among Division 1 teams this season (18 games).
• Loyola (IL) ranks 365th among Division 1 teams for opponent assist to turnover ratio this season (1.84).
• Loyola (IL) ranks 364th among Division 1 teams for steals per game this season (4.0).

Loyola Chicago Ramblers vs. Saint Louis Billikens Prediction

I’m on the Billikens here. I’ve seen nothing from Loyola Chicago to this point to suggest that the Ramblers are suddenly going to be able to find a way to compete in this game like the first few months of the season didn’t happen. Saint Louis is a different beast at home this season, and it wouldn’t shock me in the slightest if the Billikens dropped 100+ on the Ramblers here. Give me Saint Louis in a blowout.

Chris Ruffolo's Pick: Saint Louis -24.5