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Loyola Chicago vs San Francisco Prediction 12/17/2025 Today’s College Basketball Picks

Nov 8, 2023; Chicago, Illinois, USA; Florida Atlantic Owls center Vladislav Goldin (50) defends Loyola Ramblers center Miles Rubin (24) during the first half at Wintrust Arena. Mandatory Credit: David Banks-Imagn Images

Nov 8, 2023; Chicago, Illinois, USA; Florida Atlantic Owls center Vladislav Goldin (50) defends Loyola Ramblers center Miles Rubin (24) during the first half at Wintrust Arena. Mandatory Credit: David Banks-Imagn Images

MATCHUP Loyola Chicago Ramblers San Francisco Dons
Team Records 3-8 6-5
Spread +12.5 -105 -12.5 -115
Moneyline +650 -1000
Total Over 142.5 (-112) Under 142.5 (-108)
Where Chase Center, San Francisco, CA
When Wednesday, December 17, 2025
Time 10:00 PM EST
TV ESPN+

The Loyola Chicago Ramblers and the San Francisco Dons meet Wednesday in college basketball action from the Chase Center. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Loyola Chicago Ramblers vs. San Francisco Dons prediction.

Loyola Chicago Ramblers Recap

The Loyola Chicago Ramblers come into this game looking to shake off an 84-75 loss at the hands of Chicago State last time out to sit at 3-8 this season. After this game, Loyola Chicago will head on the road for a game against Santa Clara.

Ramblers Have Two-Game Win Streak Snapped

Miles Rubin leads the Ramblers in scoring and rebounding with 12.2 PPG and 7.1 RPG while Justin Moore has 12 PPG with 2.5 RPG and a team-high 4.8 APG to lead the Ramblers in assists. Deywilk Tavarez has 11.2 PPG with 2.7 RPG to cap off the group of double-digit scorers for Loyola-Chicago so far this season. Kayde Dotson has 8.5 PPG with 2.5 RPG while Chuck Love has 8.4 PPG with 2.8 RPG as well on the year. As a team, Loyola Chicago is averaging 68.3 PPG on 41.4% shooting from the field, 32.7% from three and 69% from the foul line this season. 

San Francisco Dons Recap

The San Francisco Dons come into this game looking to rebound from an 85-75 loss to Saint Louis last time out to sit at 6-5 this season. After this game, San Francisco will take on Morgan State at home.

Dons Lose 4 Of Last 5

Ryan Beasley leads the Dons in scoring with 13.8 PPG along with 2.9 RPG and 2.5 APG while Tyrone Riley IV has 11.4 PPG with 4.5 RPG and Mookie Cook has 11.1 PPG with 6.1 RPG and 2.3 APG as well this season. David Fuchs has 10.4 PPG with 6.6 RPG to cap off the group of double-digit scorers so far this season for the Dons. Junjie Wang also has 6.8 PPG with 3.2 RPG and Vukasin Masic also has a team-high 2.5 APG as well this season. As a team, San Francisco is averaging 74.6 PPG on 44.8% shooting from the field, 35.5% from three and 70.7% from the foul line this season.

Loyola Ramblers @ San Francisco Dons Betting Trends: December 17, 2025

Why the San Francisco Dons will win

Why the Loyola Ramblers will win

Total Points Facts

Matchup/League Facts

Loyola Chicago Ramblers vs. San Francisco Dons Prediction

I’m on the Ramblers and the points here. I just think we’ve hit the buy low spot on Loyola Chicago off of the loss to Chicago State. San Francisco is the better team here, but the Dons haven’t been in great form in their own right and are in danger of another loss here. Give me the Ramblers and the points.

Chris Ruffolo's Pick: Loyola Chicago +13.5

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