Louisville vs Tennessee Prediction 12/16/2025 Today’s College Basketball Picks

In this article we will formulate a Louisville vs Tennessee prediction for this College Basketball game on Tuesday, December 16th at the Food City Center in Knoxville, Tennessee. Let’s take a look at the prediction for this College Basketball matchup.

Louisville Cardinals Betting Preview

The Louisville Cardinals are 9-1 this season after they defeated Memphis by a score of 99-73 in their last game. Louisville led 57-37 at halftime and scored 42 points in the second half in the lopsided win. The Cardinals shot 56% from the field, 51% on three pointers, and 84% on free throws in the game. Ryan Conwell led Louisville with 17 points and two assists, while Mikel Brown Jr added 16 points and three assists in the win. 

Prior to that game, Louisville defeated Indiana by a score of 87-78, but lost to Arkansas by a score of 89-80 before that. The Cardinals have scored 94.3 points per game with 42.6 rebounds and 19.7 assists per game, while they have allowed 68.1 points against per game this season. Ryan Conwell is averaging 19.4 points and 4.5 rebounds per game, while Mikel Brown Jr is averaging 16.6 points and 5.1 assists per game for the Cardinals. Louisville is shooting 47.9% from the field, 77.8% on free throws, and 37.5% on three pointers this season. 

Tennessee Volunteers Betting Preview

The Tennessee Volunteers are 7-3 this year after they lost to Illinois by a score of 75-62 in their last game. Tennessee led 34-32 at halftime, but was outscored 43-28 in the second half for the loss. The Volunteers shot 37% from the field, 30% on three pointers, and 44% on free throws in the game. Ja’Kobi Gillespie led Tennessee with 15 points and five assists, while Nate Ament added nine points and four rebounds in the loss. 

Prior to that game, Tennessee lost to Syracuse by a score of 62-60 and Kansas by a score of 81-76. The Volunteers have scored 80.9 points per game with 43.3 rebounds and 18.8 assists per game, while they have allowed 66.0 points against per game this season. Ja’Kobi Gillespie is averaging 17.3 points and 5.4 assists per game, while Nate Ament is averaging 16.3 points and 7.1 rebounds per game for the Volunteers. Tennessee is shooting 46.8% from the field, 72.7% on free throws, and 34.6% on three pointers this year. 

Why the Tennessee Volunteers will win

• Tennessee has won each of its last 41 games against non-Conference opponents at Thompson-Boling Arena at Food City Center.
• Louisville has lost 13 of its last 15 night games against AP-ranked opponents.
• Louisville has lost the first half in five of its last six night games against the Southeastern Conference.

Why the Louisville Cardinals will win

• Louisville has won 19 of its last 21 night games.
• Tennessee has lost each of its last three games against non-Conference opponents.

Total Points Facts

• Forty-five of Tennessee’s last 48 night games against non-Conference opponents have produced a total of 157 or fewer points.
• Twenty-nine of Louisville’s last 35 night games have produced a total of 158 or fewer points.

Louisville vs Tennessee Prediction 

Both of these teams come into this matchup ranked in the top 25, but Tennessee has lost three straight games and has scored 62 points or fewer in back to back games. The Volunteers are shooting 47% from the field, but they have struggled on both ends of the court during this losing streak. Louisville’s lone loss came against Arkansas and they have scored at least 87 points in four of their last five games. The Cardinals are very efficient on the offensive end of the court and I haven’t seen any sign of them slowing down. Take the over here.

David Racey's Pick: Over 158.5