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Louisville vs North Carolina Prediction 2/23/2026 Today’s College Basketball Picks

Feb 21, 2026; Louisville, Kentucky, USA;  Louisville Cardinals guard Ryan Conwell (3) dribbles against Georgia Tech Yellow Jackets guard Akai Fleming (0) and center Cole Kirouac (8) during the second half at KFC Yum! Center. Louisville defeated Georgia Tech 87-70. Mandatory Credit: Jamie Rhodes-Imagn Images

Feb 21, 2026; Louisville, Kentucky, USA; Louisville Cardinals guard Ryan Conwell (3) dribbles against Georgia Tech Yellow Jackets guard Akai Fleming (0) and center Cole Kirouac (8) during the second half at KFC Yum! Center. Louisville defeated Georgia Tech 87-70. Mandatory Credit: Jamie Rhodes-Imagn Images

MATCHUP Louisville Cardinals North Carolina Tar Heels
Team Records 20-7 21-6
Spread -2.5 -105 +2.5 -115
Moneyline -148 +124
Total Over 163.5 (-105) Under 163.5 (-115)
Where Dean E. Smith Center, Chapel Hill, NC
When Monday, February 23, 2026
Time 07:00 PM EST
TV ESPN

In this article we will formulate a Louisville vs North Carolina prediction for this College Basketball game on Monday, February 23rd at the Dean E. Smith Center in Chapel Hill, North Carolina. Let’s take a look at the prediction for this College Basketball matchup.

Louisville Cardinals Betting Preview

The Louisville Cardinals are 20-7 (9-5) this season after they defeated Georgia Tech by a score of 87-70 in their last game. Louisville led 42-31 at halftime and they added 45 points in the second half in the win. The Cardinals shot 52% from the field, 45% on three pointers, and 95% on free throws in the game. Mikel Brown Jr led Louisville with 19 points and four rebounds, while J’Vonne Hadley added 17 points and five rebounds in the win. 

Prior to that game, Louisville lost to SMU by a score of 95-85, but did beat Baylor by a score of 82-71 before that. The Cardinals have scored 86.8 points per game with 39.4 rebounds and 17.8 assists per game, while they have allowed 71.8 points against per game this season. Mikel Brown Jr. is averaging 18.6 points and 4.9 assists per game, while Ryan Conwell is averaging 18.3 points and 4.8 rebounds per game for the Cardinals. Louisville is shooting 47.3% from the field, 77.9% on free throws, and 36.1% on three pointers this season. 

North Carolina Tar Heels Betting Preview

The North Carolina Tar Heels are 21-6 (9-5) this year after they defeated Syracuse by a score of 77-64 in their last game. North Carolina led 33-28 at halftime and they scored 44 points in the second half in the win. The Tar Heels shot 52% from the field, 38% on three pointers, and 54% on free throws in the game. Henri Veesaar led UNC with 19 points and three rebounds, while Luka Bogavac added 13 points and six rebounds in the win. 

Prior to that game, North Carolina lost to NC State by a score of 82-58, but did beat Pittsburgh by a score of 79-65 before that. The Tar Heels have scored 80.7 points per game with 38.8 rebounds and 16.3 assists per game, while they have allowed 70.6 points against per game this season. Caleb Wilson (out) is averaging 19.8 points and 9.4 rebounds per game, while Henri Veesaar is averaging 16.5 points and 8.8 rebounds per game for the Tar Heels. North Carolina is shooting 47.2% from the field, 68.6% on free throws, and 33.6% on three pointers this year. 

Why the North Carolina Tar Heels will win

Why the Louisville Cardinals will win

Total Points Facts

Matchup/League Facts

Louisville vs North Carolina Prediction 

North Carolina comes into this matchup after alternating wins and losses over their last five games and they are without Caleb Wilson, but they will be at home. The Tar Heels are shooting 47% from the field, but they have allowed at least 75 points in two of their last four games. Louisville is also 9-5 in conference play, but they have won six of their last seven games. The Cardinals are shooting 47% from the field and they have scored at least 82 points in five straight games. I think the loss of Wilson is too big of an issue against a solid team, so I will take Louisville here.

David Racey is 17-9 (65%) in College Basketball over the last two days. Click here for his premium plays for this today!

David Racey's Pick: Louisville -3.5

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