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Louisville vs Clemson Prediction 2/28/2026 Today’s College Basketball Picks

Clemson sophomore forward RJ Godfrey (0) recovers a loose ball near Florida State University forward Alex Steen (25) during the second half at Littlejohn Coliseum in Clemson, S.C Saturday, February 21, 2026.

Clemson sophomore forward RJ Godfrey (0) recovers a loose ball near Florida State University forward Alex Steen (25) during the second half at Littlejohn Coliseum in Clemson, S.C Saturday, February 21, 2026.

MATCHUP Louisville Cardinals Clemson Tigers
Team Records 20-8 20-8
Spread -1.5 -112 +1.5 -108
Moneyline -130 +110
Total Over 146.5 (-110) Under 146.5 (-110)
Where Littlejohn Coliseum, Clemson, SC
When Saturday, February 28, 2026
Time 02:00 PM EST
TV ESPN2
The Louisville Cardinals and Clemson Tigers meet Saturday in college basketball action at the Littlejohn Coliseum. Here’s a Louisville vs. Clemson prediction. This article will include a Louisville vs. Clemson pick.

Louisville Cardinals Betting Preview


The Louisville Cardinals lost to North Carolina, beat Georgia Tech, and play Syracuse next. Louisville has won 8 of its last 11 games.

The Louisville Cardinals are averaging 86.4 points on 47 percent shooting and allowing 72 points on 41.6 percent shooting. Mikel Brown Jr. is averaging 18.9 points and 3.4 rebounds, while Ryan Conwell is averaging 18.5 points and 4.7 rebounds. J’Vonne Hadley is the third double-digit scorer, and Isaac McKneely is grabbing 2.7 rebounds. The Louisville Cardinals are shooting 36.1 percent from beyond the arc and 77.8 percent from the free throw line. The Louisville Cardinals are allowing 32.4 percent shooting from deep and are grabbing 37.3 rebounds per game.

Clemson Tigers Betting Preview


The Clemson Tigers lost to Wake Forest and Florida State, and they play North Carolina next. Clemson has lost 4 straight games.

The Clemson Tigers are averaging 74.6 points on 45.8 percent shooting and allowing 65.6 points on 41.2 percent shooting. RJ Godfrey is averaging 11.5 points and 1.6 assists, while Carter Welling is averaging 10.3 points and 5.6 rebounds. Jestin Porter is dishing out 1.3 assists and Nick Davidson is grabbing 3.9 rebounds. The Clemson Tigers are shooting 33.9 percent from beyond the arc and 72.6 percent from the free throw line. The Clemson Tigers are allowing 31.5 percent shooting from deep and are grabbing 31.9 rebounds per game.

Why the Clemson Tigers will win

Why the Louisville Cardinals will win

Total Points: Facts

Matchup/League Facts

Louisville vs Clemson Prediction


Louisville is the more talented team, but it’s had some shaky performances lately and has lost six times on the road. Clemson has 11 home wins and is the defensive physical team that could drag Louisville into messy waters. The underdog has had success in past games and Clemson is 16-12 ATS on the season. This feels like a low-scoring ugly game. Clemson will have its chances to bully out a victory. I’ll grab the bucket with the tigers at home.

Randy Chambers's Pick: Clemson +1.5

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