| MATCHUP | Louisville Cardinals | Clemson Tigers |
|---|---|---|
| Team Records | 20-8 | 20-8 |
| Spread | -1.5 -112 | +1.5 -108 |
| Moneyline | -130 | +110 |
| Total | Over 146.5 (-110) | Under 146.5 (-110) |
| Where | Littlejohn Coliseum, Clemson, SC | |
| When | Saturday, February 28, 2026 | |
| Time | 02:00 PM EST | |
| TV | ESPN2 | |
Louisville Cardinals Betting Preview
The Louisville Cardinals lost to North Carolina, beat Georgia Tech, and play Syracuse next. Louisville has won 8 of its last 11 games.
The Louisville Cardinals are averaging 86.4 points on 47 percent shooting and allowing 72 points on 41.6 percent shooting. Mikel Brown Jr. is averaging 18.9 points and 3.4 rebounds, while Ryan Conwell is averaging 18.5 points and 4.7 rebounds. J’Vonne Hadley is the third double-digit scorer, and Isaac McKneely is grabbing 2.7 rebounds. The Louisville Cardinals are shooting 36.1 percent from beyond the arc and 77.8 percent from the free throw line. The Louisville Cardinals are allowing 32.4 percent shooting from deep and are grabbing 37.3 rebounds per game.
Clemson Tigers Betting Preview
The Clemson Tigers lost to Wake Forest and Florida State, and they play North Carolina next. Clemson has lost 4 straight games.
The Clemson Tigers are averaging 74.6 points on 45.8 percent shooting and allowing 65.6 points on 41.2 percent shooting. RJ Godfrey is averaging 11.5 points and 1.6 assists, while Carter Welling is averaging 10.3 points and 5.6 rebounds. Jestin Porter is dishing out 1.3 assists and Nick Davidson is grabbing 3.9 rebounds. The Clemson Tigers are shooting 33.9 percent from beyond the arc and 72.6 percent from the free throw line. The Clemson Tigers are allowing 31.5 percent shooting from deep and are grabbing 31.9 rebounds per game.
Why the Clemson Tigers will win
- Clemson has won 17 of its last 19 day games against conference opponents.
- Louisville has lost three of its last four road games against the Atlantic Coast Conference.
- Louisville has lost the first half in three of its last four road games against conference opponents.
Why the Louisville Cardinals will win
- Louisville has won each of its last 13 Saturday day games.
- Clemson has lost each of its last four games against conference opponents.
- Clemson has lost the first half in three of its last four games against conference opponents.
Total Points: Facts
- Each of Clemson’s last nine day games against conference opponents have produced a total of 141 or fewer points.
- Eleven of Louisville’s last 12 day games have produced a total of 148+ points.
Matchup/League Facts
- Clemson ranks 18th among Division 1 teams for opponent points per game this season (65.6).
- Clemson ranks 24th among Division 1 teams for opponent field goal attempts per game this season (54.1).
- Louisville ranks 13th among Division 1 teams for point differential per game this season (+14.4).
- Louisville ranks 16th among Division 1 teams for points per game this season (86.4).
Louisville vs Clemson Prediction
Louisville is the more talented team, but it’s had some shaky performances lately and has lost six times on the road. Clemson has 11 home wins and is the defensive physical team that could drag Louisville into messy waters. The underdog has had success in past games and Clemson is 16-12 ATS on the season. This feels like a low-scoring ugly game. Clemson will have its chances to bully out a victory. I’ll grab the bucket with the tigers at home.

