Louisville vs Cincinnati Prediction 11/21/2025 Today’s College Basketball Picks

In this article we will formulate a Louisville vs Cincinnati prediction for this College Basketball game on Friday, November 21st at the Heritage Bank Center in Cincinnati, Ohio. Let’s take a look at the prediction for this College Basketball matchup.

Louisville Cardinals Betting Preview

The Louisville Cardinals are 4-0 this year after they defeated Ohio by a score of 106-81 in their last game. Louisville led 59-44 at halftime and added 47 points in the second half for the win. The Cardinals shot 50% from the field, 46% on three pointers, and 73% on free throws in the game. Ryan Conwell led Louisville with 22 points and six rebounds, while Mikel Brown Jr added 19 points and seven assists in the win. 

Prior to that game, Louisville defeated Kentucky by a score of 96-88 and Jackson State by a score of 106-70. The Cardinals have scored 103.0 points per game with 44.3 rebounds and 22.5 assists per game, while they have allowed 71.0 points against per game this season. Mikel Brown Jr is averaging 19.3 points and 6.8 assists per game, while Ryan Conwell is averaging 19.3 points and 4.5 rebounds per game for the Cardinals. Louisville is shooting 50% from the field, 73.6% on free throws, and 36.4% on three pointers this year. 

Cincinnati Bearcats Betting Preview

The Cincinnati Bearcats are 4-0 this season after they defeated Mount St. Mary’s by a score of 72-55 in their last game. Cincinnati trailed 36-30 at halftime, but won the second half by a score of 42-19 for the victory. The Bearcats shot 38% from the field, 21% on three pointers, and 60% on free throws in the game. Day Day Thomas led Cincinnati with 16 points and five assists, while Baba Miller added 13 points and 11 rebounds in the win. 

Prior to that game, Cincinnati defeated Dayton by a score of 74-62 and Georgia State by a score of 74-64. The Bearcats have scored 78.5 points per game with 41.3 rebounds and 16.5 assists per game, while they have allowed 61.0 points against per game this season. Baba Miller is averaging 15.8 points and 10.5 rebounds per game, while Day Day Thomas is averaging 14.0 points and 4.0 assists per game for the Bearcats. Cincinnati is shooting 44.3% from the field, 63.4% on free throws, and 29.9% on three pointers this season. 

Why the Louisville Cardinals will win

• Louisville has won 18 of its last 19 night games against non-AP-ranked opponents.
• Cincinnati has lost each of its last eight night games against Top 10 AP-ranked opponents.
• Cincinnati has lost the first half in four of its last five night games against Top 10 AP-ranked opponents.

Total Points Facts

• Each of Cincinnati’s last 16 games against non-Conference opponents have produced a total of 163 or fewer points.
• Each of Louisville’s last 12 night games against non-AP-ranked opponents at a neutral venue have produced a total of 158 or fewer points.

Louisville vs Cincinnati Prediction

Both of these teams come into this matchup with a 4-0 record to start the season, so this should be a pretty good game. Cincinnati had some first half struggles against Mount St. Mary’s last time out, but they had a huge second half for the win. The Bearcats are shooting 44% from the field and they have allowed 64 points or fewer in all four games. Louisville is shooting 50% from the field and they have scored at least 96 in all four games. The Cardinals are not great on defense, but they are elite offensively. Take Louisville to cover here.

David Racey's Pick: Louisville -8.5