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Kentucky vs Louisville Prediction 11/11/2025 Today’s College Basketball Picks

Nov 6, 2025; Louisville, Kentucky, USA;  Jackson State Tigers guard Daeshun Ruffin (24) scrambles for the ball with Louisville Cardinals forward Khani Rooths (9) during the second half at KFC Yum! Center. Louisville defeated Jackson State 106-70. Mandatory Credit: Jamie Rhodes-Imagn Images

Nov 6, 2025; Louisville, Kentucky, USA; Jackson State Tigers guard Daeshun Ruffin (24) scrambles for the ball with Louisville Cardinals forward Khani Rooths (9) during the second half at KFC Yum! Center. Louisville defeated Jackson State 106-70. Mandatory Credit: Jamie Rhodes-Imagn Images

MATCHUP Wildcats Kentucky Cardinals Louisville
Team Records 2-0 2-0
Spread +4.5 -110 -4.5 -110
Moneyline +150 -180
Total Over 175.5 (-105) Under 175.5 (-115)
Where KFC Yum! Center, Louisville, KY
When Tuesday, November 11, 2025
Time 08:00 PM EST
TV ESPN
The Kentucky Wildcats and Louisville Cardinals meet Tuesday in the college basketball action at the KFC Yum! Center. Here’s a Kentucky vs Louisville Prediction. This article will include a Kentucky vs Louisville Pick.

Kentucky Wildcats Betting Preview


The Kentucky Wildcats beat Nicholls and Valparaiso, and they play Eastern Illinois and Michigan State next. Kentucky has won 5 of its last 6 regular season games.

The Kentucky Wildcats are averaging 92 points on 50.8 percent shooting and allowing 55 points on 29.2 percent shooting. Collin Chandler is averaging 14.5 points and 3.5 rebounds, while Otega Oweh is averaging 14 points and 4 rebounds. Malachi Moreno is the third double-digit scorer and Denzel Aberdeen is dishing 4 assists. The Kentucky Wildcats are shooting 32.7 percent from beyond the arc and 70.8 percent from the free throw line. The Kentucky Wildcats are allowing 20.7 percent shooting from deep and are grabbing 43 rebounds per game.

Louisville Cardinals Betting Preview


The Louisville Cardinals beat South Carolina State and Jackson State, and they play Ohio and Cincinnati next. Louisville has won 13 of its last 14 regular season games.

The Louisville Cardinals are averaging 105 points on 52.7 percent shooting and allowing 57.5 points on 31.7 percent shooting. Khani Rooths is averaging 18 points and 8.5 rebounds, while Ryan Conwell is averaging 15.5 points and 5.5 rebounds. Mikel Brown Jr. is the third double-digit scorer and J’Vonne Hadley is grabbing 9 rebounds. The Louisville Cardinals are shooting 33.8 percent from beyond the arc and 76.5 percent from the free throw line. The Louisville Cardinals are allowing 28.3 percent shooting from deep and are grabbing 46 rebounds per game.

Why the Louisville Cardinals will win

Why the Kentucky Wildcats will win

Total Points Facts

Matchup/League Facts

Kentucky vs Louisville Prediction


Louisville is going to get the benefit of the doubt because it’s at home and this is one of the more talented teams It’s had in a while. However, the value is with Kentucky and the points. As usual, Kentucky is one of the more talented teams in the country, and you’re not going to get the Wildcats as underdogs often the rest of the way. Kentucky has depth and has shown the ability to dig in defensively. Kentucky has won 8 of the last 10 games against Louisville and has outright won 10 of its last 16 games as an underdog. Any time I can get one of the best teams in the country in the plus money role, I’m going to take it, as it will pay off long term. Give me Kentucky.

Randy Chambers's Pick: Kentucky +4.5

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