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Jackson State vs Louisville Prediction 11/6/2025 Today’s College Basketball Picks

Louisville Cardinals guard J'Vonne Hadley (1) tries to drive around Creighton Bluejays forward Jackson McAndrew (23) during the second half in the first round game of the 2025 NCAA men's basketball tournament at Rupp Arena in Lexington, Kentucky Thursday March 20, 2025.

Louisville Cardinals guard J'Vonne Hadley (1) tries to drive around Creighton Bluejays forward Jackson McAndrew (23) during the second half in the first round game of the 2025 NCAA men's basketball tournament at Rupp Arena in Lexington, Kentucky Thursday March 20, 2025.

MATCHUP Tigers Jackson State Cardinals Louisville
Team Records 0-1 1-0
Where KFC Yum! Center, Louisville, KY
When Thursday, November 6, 2025
Time 07:00 PM EST
TV ACC Extra
In this article, we will formulate a Jackson State vs Louisville Prediction for this College Basketball game on Thursday, November 6th. Let’s take a look at the prediction for this College Basketball matchup.

Louisville Cardinals Preview

The Louisville Cardinals have a 1-0 record this season and are 1-0 ATS and 0-1 in Over/Under. They are coming off a 104-45 win at home against South Carolina State. The Cardinals shot 54.8% from the field and 44.4% from beyond the arc. They made 76.5% of their free throws and grabbed 46 rebounds, while dishing out 22 assists and committing 11 turnovers. They had 20 fast break points and 44 points in the paint.

Sananda Fru, Ryan Conwell, Mikel Brown Jr., Isaac McKneely and J’Vonne Hadley were the starting five for Louisville, with McKneely being the top scorer with 17 points and 4 rebounds, while shooting 46.2% from the field. J’Vonne Hadley followed with 13 points and 9 rebounds, while shooting 71.4% from the field. Ryan Conwell added 12 points and 3 rebounds.

Jackson State Tigers Preview

The Jackson State Tigers have a 0-1 record this season and are 0-1 ATS and 1-0 in Over/Under. They are coming off a 55-113 loss on the road against Illinois. The Tigers shot 30.6% from the field and 24.1% from beyond the arc. They made 71.4% of their free throws and grabbed 19 rebounds, while dishing out 5 assists and committing 11 turnovers. They had 17 fast break points and 20 points in the paint.

Kobe Butler, Devin Ree, Dorian McMillian, Jayme Mitchell Jr. and Daeshun Ruffin were the starting five for Jackson State, with Ree being the top scorer with 19 points and 1 rebound, while shooting 63.6% from the field. Daeshun Ruffin followed with 12 points and 5 rebounds, while shooting 45.5% from the field. Jayme Mitchell Jr. added 7 points and one rebound.

Jackson State Tigers @ Louisville Cardinals Betting Trends: November 6, 2025


Why the Louisville Cardinals will win

Why the Jackson State Tigers will win

Total Points Facts

Matchup/League Facts

Jackson State vs Louisville Prediction

Louisville has won both meetings against Jackson State, both at home, by 62-45 and 84-53. In this Jackson State vs Louisville Prediction, Louisville is coming as -34.5 home favorites. Louisville was the superior team last season and they started the new season on the right foot, with a dominating 59-point win against South Carolina State. On the flip side, Jackson State is coming off a brutal 58-point road defeat to Illinois and last season’s defensive woes seems to be continuing this year as well. Louisville is by far the better team in this matchup and I expect a comfortable win in this one. Take Louisville and lay the points at home.

Nikos Lagouretos's Pick: Louisville -34.5

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