Grambling State vs Iowa State Prediction 11/6/2025 Today’s College Basketball Picks

Nikos Lagouretos

5 hours ago

Nov 3, 2025; Ames, Iowa, USA; Iowa State Cyclones guard Nate Heise (0) defends Fairleigh Dickinson Knights guard Eric Parnell (7) at James H. Hilton Coliseum. Mandatory Credit: Reese Strickland-Imagn Images

MATCHUP	Tigers Grambling State	Cyclones Iowa State
Team Records	1-0	1-0
Where	Hilton Coliseum, Ames, IA
When	Thursday, November 6, 2025
Time	08:00 PM EST
TV	ESPN+

In this article, we will formulate a Grambling vs Iowa State Prediction for this College Basketball game on Thursday, November 6th. Let’s take a look at the prediction for this College Basketball matchup.

Iowa State Cyclones Preview

The Iowa State Cyclones have a 1-0 record this season and are 1-0 ATS and 0-1 in Over/Under. They are coming off an 88-50 win at home against Fairleigh Dickinson. The Cyclones shot 52.2% from the field and 44.4% from beyond the arc. They made 66.7% of their free throws and grabbed 41 rebounds, while dishing out 19 assists and committing 9 turnovers. They had 14 fast break points and 44 points in the paint.

Blake Buchanan, Joshua Jefferson, Milan Momcilovic, Killyan Toure and Tamin Lipsey were the starting five for Iowa State, with Momcilovic being the top scorer with 29 points and 3 rebounds, while shooting 68.8% from the field. Tamin Lipsey followed with 18 points and 6 rebounds, while shooting 61.5% from the field. Joshua Jefferson added 14 points and 10 rebounds.

Grambling Tigers Preview

The Grambling Tigers have a 1-0 record this season and are 0-0 ATS and 0-0 in Over/Under. They are coming off a 91-47 win at home against Huston-Tillotson. The Tigers shot 46.3% from the field and 21.7% from beyond the arc. They made 75.0% of their free throws and grabbed 49 rebounds, while dishing out 14 assists and committing 15 turnovers. They had 30 fast break points and 50 points in the paint.

Antonio Munoz, Roderick Coffee III, Jimel Lane, Randarius Jones and Derrius Ward were the starting five for Grambling, with Lane being the top scorer with 15 points and 3 rebounds, while shooting 50.0% from the field. Antonio Munoz followed with 12 points and 4 rebounds, while shooting 50.0% from the field. Roderick Coffee III added 10 points and 5 rebounds.

Grambling State Tigers @ Iowa State Cyclones Betting Trends: November 6, 2025

Why the Iowa State Cyclones will win

Iowa State has won each of its last 35 games against non-Conference opponents at James H. Hilton Coliseum.
Grambling State has lost each of its last 11 games against non-Conference opponents.
Iowa State has won the first half in each of its last 35 games against non-Conference opponents at James H. Hilton Coliseum.

Why the Grambling State Tigers will win

Grambling State has won three of its last four games.
Grambling State has won the first half in five of its last six games.

Grambling vs Iowa State Prediction

Iowa State has won both meetings against Grambling, by 92-37 in 2023 and by 82-47 in 2021, as both games went under the total.

In this Grambling vs Iowa State Prediction, Iowa State is coming as -33.5 home favorites. Iowa State is the superior team in this matchup and are coming off a successful campaign last season, while on the other hand, Grambling were terrible last season and had a bottom-35 offense with just 66.8 points per game. On the flip side, Iowa State had the 34th-best offense last season, scoring 13.5 points per game more than Grambling and I expect them to win comfortably today at home. Take Iowa State and lay huge number in this one.