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Chicago State vs St. Louis Prediction 11/6/2025 Today’s College Basketball Picks

Indiana State Sycamores center Robbie Avila (21) goes in for a lay-up Thursday, April 4, 2024, during the NIT championship game at Hinkle Fieldhouse in Indianapolis. The Seton Hall Pirates defeated the Indiana State Sycamores, 79-77.

Indiana State Sycamores center Robbie Avila (21) goes in for a lay-up Thursday, April 4, 2024, during the NIT championship game at Hinkle Fieldhouse in Indianapolis. The Seton Hall Pirates defeated the Indiana State Sycamores, 79-77.

MATCHUP Cougers Chicago State Billikens St. Louis
Team Records 0-1 1-0
Where Chaifetz Arena, St. Louis, MO
When Thursday, November 6, 2025
Time 08:00 PM EST
TV ESPN+
The Chicago State Cougars and the Saint Louis Billikens meet Thursday in college basketball action from the Chaifetz Arena. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago State Cougars vs. Saint Louis Billikens prediction.

Chicago State Cougars Recap

The Chicago State Cougars come into this game looking to rebound from a 92-62 loss at the hands of the Depaul Blue Demons last time out to start the year at 0-1. 

Cougars Looking To Rebound

Stephen Byard leads the Cougars with 16 points on 5 of 8 shooting while Marcus Tankersley had 16 points with a team-high 9 rebounds, shooting 6 of 11 from the floor. Doyel Cockrill III added 10 points to cap off the trio of double-digit scorers for Chicago State in the losing effort. CJ Ray added 4 points to match his 4 rebounds while Braelon Bush added 6 points with 4 rebounds, 3 assists and 2 steals as well in the loss.

Saint Louis Billikens Recap

The Saint Louis Billikens come into this game looking to add on to their season-opening 92-67 win over SE Missouri State last time out to start the year at 1-0. 

Billikens Looking To Remain Unbeaten

Robbie Avila led the Billikens with 18 points on 6 of 13 shooting with 3 threes and 11 rebounds for the double-double while Amari McCottry added 16 points on 7 of 8 shooting. Kellen Thames added 12 points with 4 rebounds, a team-high 3 assists and 3 steals as well in the win. Dion Brown chipped in 11 points with 11 rebounds and 3 assists for his own double-double and Quentin Jones added 10 points with 7 rebounds to cap off the group of double-digit scorers for Saint Louis in the winning effort. 

Chicago State Cougars @ Saint Louis Billikens Betting Trends: November 6, 2025


Why the Saint Louis Billikens will win

Why the Chicago State Cougars will win

Total Points Facts

Chicago State Cougars vs. Saint Louis Billikens Prediction

I’m on the Billikens here. It’s a big number, but one that I do think that the Billikens will be able to cover as they’re simply the better and more complete team in this matchup. Chicago State is a team I’m going to keep my eye on this season with a new head coach and a new identity, but I think that Saint Louis ends up being too much here. Give me the Billikens.

Chris Ruffolo's Pick: St. Louis -28.5

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