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Butler vs Villanova Prediction 2/25/2026 Today’s College Basketball Picks

Feb 21, 2026; Philadelphia, Pennsylvania, USA; Villanova Wildcats center Braden Pierce (17) dunks the ball against the UConn Huskies during the second half at Xfinity Mobile Arena. Mandatory Credit: Bill Streicher-Imagn Images

Feb 21, 2026; Philadelphia, Pennsylvania, USA; Villanova Wildcats center Braden Pierce (17) dunks the ball against the UConn Huskies during the second half at Xfinity Mobile Arena. Mandatory Credit: Bill Streicher-Imagn Images

MATCHUP Butler Bulldogs Villanova Wildcats
Team Records 15-13 21-6
Spread +9.5 -105 -9.5 -115
Moneyline +410 -550
Total Over 146.5 (-110) Under 146.5 (-110)
Where Finneran Pavilion, Villanova, PA
When Wednesday, February 25, 2026
Time 07:00 PM EST
TV FS1

In this article, we will formulate a Butler vs Villanova Prediction for this college basketball game on Wednesday, February 25th. Let’s take a look at the prediction for this college basketball matchup.

Villanova Wildcats Preview

The Villanova Wildcats have a 21-6 overall record and a 12-4 record in the Big East. They are coming off a 73-63 home loss against Connecticut and their previous three games were a 92-89 road win against Xavier, an 80-69 road win against Creighton and a 77-74 home win against Marquette.

Offensively, Villanova averages 77.7 points per game, while allowing 70 points per game defensively. The Wildcats shoot with 46% from the field and grab 35.2 rebounds per game, while dishing out 15.4 assists per game. They average 2.3 blocks per game and 7.6 steals per game defensively.

Tyler Perkins leads Villanova in scoring, with an average of 13.8 points per game, while shooting with 44.4% from the field and 75.3% from the free throw line. Duke Brennan is the team’s leading rebounder with 10.4 per game. Acaden Lewis leads the team in assists with 5.3 per game.

Butler Bulldogs Preview

The Butler Bulldogs have a 15-13 overall record and a 6-11 record in the Big East. They are coming off an 80-75 home win against Xavier and their previous three games were a 93-89 road win against Georgetown, a 63-56 home loss against Seton Hall and an 80-70 home loss against Connecticut.

Offensively, Butler averages 80.2 points per game, while allowing 77.2 points per game defensively. The Bulldogs shoot with 45% from the field and grab 37.7 rebounds per game, while dishing out 15.8 assists per game. They average 3.3 blocks per game and 6.6 steals per game defensively.

Finley Bizjack leads Butler in scoring, with an average of 17.5 points per game, while shooting with 43.9% from the field and 85.7% from the free throw line. Michael Ajayi is the team’s leading rebounder with 11.1 per game, adding a team-high 3.2 assists.

Butler Bulldogs @ Villanova Wildcats Betting Trends: February 25, 2026

Why the Villanova Wildcats will win

Why the Butler Bulldogs will win

Total Points Facts

Butler vs Villanova Prediction      

In this Butler vs Villanova Prediction, Villanova is coming as -9.5 home favorites. Villanova has been the better team this season with both a better overall record and a better ATS record. They have been red-hot lately with a 6-1 record in their last 7 games, while on the other hand, Butler is 2-6 in its last 8 games, while having an inferior defense, allowing 7.2 points pe game more than the hosts. Villanova is 7-2 in their last 9 head-to-head matches and dominated their previous meeting this season by 18 points on the road, so I expect them to win this one comfortably and cover the spread.

Nikos Lagouretos's Pick: Villanova -9.5

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