Clemson vs Louisville Prediction 3/14/25 College Basketball Picks

Louisville (26-6) vs Clemson (27-5)

Game Info: Friday, March 14, 2025 at 9:30 pm (Spectrum Center)

Betting Odds: Louisville +1 -- Over/Under: 141.5 Click Here for the Latest Odds

Where to Watch: ESPN

The Clemson Tigers are facing the Louisville Cardinals on Friday, March 14th at the Spectrum Center, in the second ACC semifinal between the 2nd seed and the 3rd seed of the conference. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Clemson Tigers vs Louisville Cardinals Prediction. We will examine:

The Louisville Cardinals recent form and player performance

The Clemson Tigers recent form and player performance

Recent betting trends and streaks involving the Louisville Cardinals

Recent betting trends and streaks involving the Clemson Tigers

Recent betting trends in games played between the Clemson Tigersand Louisville Cardinals

A summary that ties it all together and produces a favorable betting outcome for Clemson Tigers vs Louisville Cardinals game

Louisville Cardinals Preview

The Louisville Cardinals have a 26-6 record this season and finished in the 2nd place of the ACC. Louisville is coming off a 75-73 win over Stanford in the conference quarterfinals. The Cardinals are 19-13 against the spread, and 11-21 in over/under. 

Offensively, Louisville is averaging 79.2 points per game, which ranks 54th in the nation. Defensively, they are allowing 68.7 points per game (78th). The Cardinals shoot with 45.7% from the field (136th), and with 33.3% from beyond the arc (228th). The Cardinals shoot with 74.5% from the free throw line (81st), and are grabbing 34.9 rebounds per game (42th).

Chucky Hepburn leads Louisville in scoring this season, with an average of 16.3 points, 3.5 rebounds and a team-high 5.9 assists, while Terrence Edwards adds 15.8 points and 4 rebounds per game.

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Clemson Tigers Preview

The Clemson Tigers have a 27-5 record this season and were placed 3rd place in the Atlantic Coast. The Tigers are coming off a 57-54 win over SMU in the conference quarterfinals. The Tigers are 20-12 against the spread, and 16-16 in over/under.

Offensively, Clemson is averaging 76.4 points per game, which ranks 95th in the nation. Defensively, they are allowing 65.3 points per game (30th). The Tigers shoot with 46.8% from the field (64th), and with 37.3% from beyond the arc, which is the 24th-best nationally. The Tigers shoot with 76.4% from the free throw line (40th), and are grabbing 32.3 rebounds per game (152nd).

Chase Hunter leads Clemson in scoring this season, with an average of 16 points and 2.9 rebounds, while Ian Schieffelin adds 12.9 points and a team-high 9.3 rebounds per game.

Why the Louisville Cardinals will win

  • Louisville has won each of its last 12 night games.
  • Clemson has lost six of its last eight games against AP-ranked opponents at a neutral venue.
  • Louisville has won the first half in 21 of its last 22 games against the Atlantic Coast Conference.

Why the Clemson Tigers will win

  • Louisville has lost each of its last 11 night games against AP-ranked opponents.
  • Clemson has won each of its last nine games.
  • Louisville has lost the first half in 10 of its last 11 night games against AP-ranked opponents.

Total Points Facts

  • Nine of Clemson's last 10 Conference Tournament games have produced a total of 134 or fewer points.
  • Each of Louisville's last four night games against Top 10 AP-ranked opponents at a neutral venue have produced a total of 147+ points.

Matchup/League Facts

  • Louisville ranks 17th among Division 1 teams for three-point field goal attempts per game this season (29.0).
  • Louisville ranks 25th among Division 1 teams for net rating this season (+15.7).
  • Clemson ranks 11th among Division 1 teams for opponent assist to turnover ratio this season (0.79).
  • Clemson ranks T17th among Division 1 teams for opponent free throws made per game this season (10.5).

Clemson Tigers vs Louisville Cardinals Prediction

Both teams are tied 5-5 wins in their last 10 meetings but Louisville is 5-0 against the spread in their last 5 meetings. Under is 4-2 in their last 6 meetings, and in their previous meeting earlier this season, Louisville won 74-64 at home, covering the spread, as the game went under the point total.  

In this Clemson Tigers vs Louisville Cardinals Prediction, Clemson is coming as -1-point favorites. Both teams have almost identical records this season, and both have exactly 9 wins away from home. Both teams are coming into this matchup red-hot, as Louisville has 10 consecutive wins, and are 3-1 against the spread in their last 4, while Clemson is coming off 9 straight wins and are 7-2 against the spread, so I see no value between two streaky teams. Both teams have been involved in some lower-scoring games lately, as they are 7-2 to the under in their last 9 games combined. Their previous meeting this season had only 138 total points, and today’s total is set at 141.5. With both teams boasting top-80 defenses, allowing 134 points per game combined, I am going with the under the total in this one.

Nikos’s Pick Under 141.5

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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