Wyoming vs Colorado State Prediction 9/5/2026 Today’s College Football Picks

The Wyoming Cowboys and the Colorado State Rams meet in week 1 college football action from Canvas Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Wyoming Cowboys vs. Colorado State Rams Prediction.

Wyoming Cowboys Recap

The Wyoming Cowboys come into the 2026 season looking to shake off their 2025 season where they went just 4-8 overall including a 2-6 mark in Mountain West conference play. The Cowboys bring in Tyler Hughes from William & Mary to lead the QB room after posting a 20-3 TD-INT ratio last season while also rushing for another 11 TDs. On defense, just 4 of the top 13 tacklers are back with Ethan Stuhlstaz back at linebacker and Jones Thomas back in the secondary for the Cowboys.

Colorado State Rams Team Preview

The Colorado State Rams will look for a much different finish to 2026 after going just 2-10 in 2025, which led to the Rams hiring Jim Mora Jr as head coach. This is a borderline restart for Colorado State with Hauss Hejny coing in from OK State and TCU stops and Ksaan Farrar to battle for reps at QB1. The challenge for Colorado State defensively, will be making up for the loss of 7 of the 8 top tacklers from last year’s team, but this is still looking like a solid defensive front for the squad from Fort Collins in 2026.

Wyoming Cowboys @ Colorado State Rams Betting Trends: Week 1

Why the Colorado State Rams will win

• Wyoming has lost each of its last 11 September games as a road underdog.
• The home team has won six of Wyoming’s last seven games.
• The home team has covered the spread in each of the last seven games between Wyoming and Colorado State.
• Wyoming has failed to cover the spread in each of its last four games.
• Wyoming has lost the first half in each of its last eight September games as an underdog.
• The home team has won the first quarter in each of the last four games between Wyoming and Colorado State.

Why the Wyoming Cowboys will win

• Colorado State has lost each of its last eight season openers.
• Wyoming has won three of its last four games as an underdog against Colorado State.
• Colorado State has failed to cover the spread in seven of its last eight season openers.
• The road team has covered the spread in three of Colorado State’s last four games.
• Colorado State has lost the first half in each of its last six games.
• Wyoming has won the first quarter in four of its last six games as an underdog against teams from Colorado.

Total Points Facts

• Each of Wyoming’s last six games have gone UNDER the total points line.
• Eight of Colorado State’s last nine games as a favorite in Colorado have gone UNDER the total points line.

Colorado State Rams Player Prop Facts

• Jace Bellah ranked T23rd amongst FBS players for interceptions (4) last season.

Wyoming Cowboys Player Prop Facts

• Bart Edmiston Jr. ranked 15th amongst qualified players for gross average yards per punt (46.1) last season.

Matchup/League Facts

• Colorado State ranked 135th among FBS teams for Q2 opponent points per game last season (12.0).
• Colorado State ranked 135th among FBS teams for average point differential in second quarters last season (-7.8).
• Wyoming ranked 2nd among FBS teams for red zone percentage against last season (68.8).
• Wyoming ranked 135th among FBS teams for Q2 points per game last season (3.1).

Wyoming Cowboys vs. Colorado State Rams Prediction

I’m on the under in this one. There’s a lot of unknowns within both of these teams, especially at quarterback, so I think this is a game where possession and clock control is everything. I look for both of these teams to try to instill a ground game and hold on to the ball as long as they can and I am expecting a 21-17 kind of game, so I’ll roll with the under in this one.

Chris Ruffolo's Pick: Under 46.5