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Western Kentucky vs LSU Prediction 11/22/2025 Today’s College Football Picks

Florida State Seminoles linebacker Tatum Bethune (15) fights off LSU Tigers running back Josh Williams (27) during a game at Camping World Stadium on Sunday, Sept. 3, 2023.

Florida State Seminoles linebacker Tatum Bethune (15) fights off LSU Tigers running back Josh Williams (27) during a game at Camping World Stadium on Sunday, Sept. 3, 2023.

MATCHUP Western Kentucky Hilltoppers LSU Tigers
Team Records 8-2 6-4
Spread +23.5 -112 -23.5 -108
Moneyline +1200 -2400
Total Over 50.5 (-105) Under 50.5 (-115)
Where Tiger Stadium (LA), Baton Rouge, LA
When Saturday, November 22, 2025
Time 07:45 PM EST
TV SEC Network
In this article, we will formulate a Western Kentucky vs LSU Prediction for this College Football Week 13 game on Saturday, November 22nd. Let’s take a look at the prediction for this College Football matchup.

LSU Fighting Tigers Preview


LSU has a 6-4 record this season and is sitting 10th in the SEC. They are 3-7 ATS, 3-7 in Over/Under and have a 5-1 home record and a 1-3 away record. LSU is coming off a 23-22 home win against Arkansas and will face Oklahoma next.

Offensively, LSU averages 23.6 points per game, ranking 98th in the nation, while defensively, they allow 19.3 points per game, which is 20th. LSU averages 346.6 total yards per game (240.2 passing and 106.4 rushing), while allowing 329.1 total yards per game (130.9 rushing and 198.2 passing).

Garrett Nussmeier leads LSU with 1,927 passing yards with 67.4% completed passes and 12 touchdowns. Caden Durham leads the team in rushing yards with 447, while Zavion Thomas has a team-high 31 receptions for 396 receiving yards. Defensively, A.J. Haulcy has a team-high 72 total tackles (41 of them solo), while Harold Perkins leads the team in sacks, with 4, and A.J. Haulcy has a team-high 2 interceptions.

Western Kentucky Hilltoppers Preview


Western Kentucky has an 8-2 record this season and is sitting 2nd in the CUSA. They are 8-2 ATS, 5-5 in Over/Under and have a 5-1 home record and a 3-1 away record. Western Kentucky is coming off a 42-26 home win against Middle Tennessee State and will face Jacksonville State next.

Offensively, Western Kentucky averages 31.3 points per game, ranking 47th in the nation, while defensively, they allow 23.1 points per game, which is 55th. Western Kentucky averages 432.9 total yards per game (296.1 passing and 136.8 rushing), while allowing 399.0 total yards per game (175.7 rushing and 223.3 passing).

Maverick McIvor leads Western Kentucky with 1,863 passing yards with 67.1% completed passes and 12 touchdowns. George Hart III leads the team in rushing yards with 258, while Quincy Burroughs has a team-high 87 receptions for 796 receiving yards. Defensively, Jaylen Wester has a team-high 64 total tackles (28 of them solo), while Dominic Oliver leads the team in sacks, with 3.

Western Kentucky Hilltoppers @ LSU Tigers Betting Trends: Week 13


Why the LSU Tigers will win

Why the Western Kentucky Hilltoppers will win

Total Points Facts

LSU Tigers Player Prop Facts

Western Kentucky Hilltoppers Player Prop Facts

Matchup/League Facts

Western Kentucky vs LSU Prediction


In this Western Kentucky vs LSU Prediction, LSU is coming as -23.5-point home favorites, with the total set at 50 points. The wrong team is favored in this matchup, as Western Kentucky has more overall wins this season and have been very good on the road. On top of that, they have been in excellent form lately, with a 6-1 record in its last 7 games, while on the other hand LSU is 1-3 in its last 4. Western Kentucky also has a superior offense, scoring 7.7 points per game more than LSU, so the value here lies with the road team. Take Western Kentucky and the +23.5 points in this one.

Nikos Lagouretos's Pick: Western Kentucky +23.5

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