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Wake Forest vs Purdue Prediction 9/12/2026 Today’s College Football Picks

Purdue's Travis Terrell Jr. (20) rushes the football on Friday, Sept. 4, 2026, during the NCAA football game between the Purdue Boilermakers and the Indiana State Sycamores at Ross-Ade Stadium in West Lafayette, Ind.

Purdue's Travis Terrell Jr. (20) rushes the football on Friday, Sept. 4, 2026, during the NCAA football game between the Purdue Boilermakers and the Indiana State Sycamores at Ross-Ade Stadium in West Lafayette, Ind.

MATCHUP Wake Forest Demon Deacons Purdue Boilermakers
Team Records 1-0 1-0
Spread -3 -112 +3 -108
Moneyline -155 +130
Total Over 49.5 (-115) Under 49.5 (-105)
Where Ross-Ade Stadium, West Lafayette, IN
When Saturday, September 12, 2026
Time 12:00 PM EDT
TV FS1
In this article, we will formulate a Wake Forest vs Purdue Prediction for this College Football Week 2 matchup on Saturday, September 12th. Let’s take a look at the prediction for this College Football matchup.

Purdue Boilermakers Preview


The Purdue Boilermakers have a 1-0 record this season and are coming off a 44-19 home victory over Indiana State, where they outgained their opponents 523-284 yards and had 74 total plays. Purdue had 346 passing yards, 177 rushing yards, and 27/34 completed passes. They were 6/11 on third down conversions, had 9-85 penalties and won the turnover battle by 0-1.

Ryan Browne led Purdue with 23/29 passes and 317 passing yards. Fame Ijeboi had a team-high 87 rushing yards, while Asaad Waseem caught 6 passes for a team-high 107 receiving yards. Defensively, Jojo Hayden led the Boilermakers with 5 total tackles, 2 of them solo, and Ian Jeffries led the team with one sack.

Wake Forest Demon Deacons Preview


The Wake Forest Demon Deacons have a 1-0 record this season and are coming off a 38-16 home victory over Akron, where they outgained their opponents 559-305 yards and had 68 total plays. Wake Forest had 356 passing yards, 203 rushing yards, and 22/35 completed passes. They were 7/15 on third down conversions, had 11-115 penalties and won the turnover battle by 0-1.

Gio Lopez led Wake Forest with 21/32 passes and 350 passing yards. Ty Clark III had a team-high 105 rushing yards, while Carlos Hernandez caught 5 passes for a team-high 165 receiving yards. Defensively, Frank Cusano led the Demon Deacons with 9 total tackles, 2 of them solo, and Braylon Johnson led the team with one sack.

Wake Forest Demon Deacons @ Purdue Boilermakers Betting Trends: Week 2


Why the Purdue Boilermakers will win

Why the Wake Forest Demon Deacons will win

Total Points Facts

Purdue Boilermakers Player Prop Facts

Wake Forest Demon Deacons Player Prop Facts

Matchup/League Facts

Wake Forest vs Purdue Prediction


In this Wake Forest vs Purdue Prediction, Wake Forest is coming as -2.5 road favorites. Both teams are coming off comfortable wins in their opening games of the season, winning by 25 and 18 points respectively. Purdue will play its second straight game at home to start the season and they failed to cover the spread last week and are 1-4 against the spread at home in their last 5 games going back to last season. On the flip side, Wake Forest was an excellent covering team last season with 9-4 ATS and were 4-2 ATS in their last 6 road games last season. Take Wake Forest and lay the small number in this one.  

Nikos Lagouretos's Pick: Wake Forest -2.5

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