USC vs Oregon Prediction 11/22/2025 Today’s College Football Picks

Andrew Jett

4 hours ago

Nov 14, 2025; Eugene, Oregon, USA; The Oregon Ducks cheerleaders perform during the second half in a game between the Oregon Ducks and the Minnesota Golden Gophers at Autzen Stadium. Mandatory Credit: Troy Wayrynen-Imagn Images

MATCHUP	USC Trojans	Oregon Ducks
Team Records	8-2	9-1
Spread	+9.5 -112	-9.5 -108
Moneyline	+285	-360
Total	Over 59.5 (-112)	Under 59.5 (-108)
Where	Autzen Stadium, Eugene, OR
When	Saturday, November 22, 2025
Time	03:30 PM EST
TV	CBS

The USC Trojans and the Oregon Ducks meet Saturday in college football action from Autzen Stadium. Here’s a USC vs Oregon prediction. We will look at this from a betting perspective and determine the best USC vs Oregon pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

USC Trojans Betting Preview

The Trojans got off to a nice start this year, beating Missouri State, Georgia Southern, Purdue and Michigan State before a loss to Illinois. USC went 3-1 over the next four, losing to Notre Dame among wins versus Michigan, Nebraska and Northwestern. In the 38-17 win over the Wildcats, the Trojans put up points in every quarter—including double-digits in two of them. The offense managed 482 total yards with 24 first downs and 7.5 yards per play. Defensively USC held the Wildcats to 280 yards, 13 first downs and 4-of-12 on third-down tries.

In their Saturday matchup with Iowa, USC was in trouble at the break facing a 21-10 deficit. The Trojans woke up on a 16-0 run from there though, ultimately powering out a 26-21 comeback victory at home. QB Jayden Maiava had a 23-of-32 line for 254 yards and a score. King Miller led the rush on 19 carries for 83 yards and Bryan Jackson had four totes for 14 yards and two touchdowns. Lead receiver Makai Lemon caught 10 balls for 153 yards and a touchdown.

Oregon Ducks Betting Preview

Over on the Ducks’ side, they rolled past Montana State, Oklahoma State, Northwestern, Oregon State and Penn State before a loss to Indiana on October 11. Oregon followed that up with wins over Rutgers, Wisconsin and Iowa in the next trio. In the 18-16 escape on the road versus Iowa, Oregon scored in every quarter—including 10 in the second. The offense gained 373 total yards with 261 rush yards, 6.5 yards per play and 19 first downs but went just 3-of-10 on third downs. Defensively Oregon had two fumble recoveries and 18 first downs allowed.

Matched up versus Minnesota on Friday, the Ducks jumped out to a 28-6 first-half lead. Oregon cruised from there in a 42-13 blowout victory at home. QB Dante Moore had 306 yards and two scores on a 27-of-30 line and lead rusher Noah Whittington had 72 yards and a score on eight carries. Kenyon Sadiq put up eight catches for 96 yards and a touchdown as well.

USC Trojans @ Oregon Ducks Betting Trends: Week 13

Oregon Ducks Player Prop Facts

Heading into Week 13, Dante Moore ranks 3rd amongst qualified players for passer rating (118.1) this season.

USC Trojans Player Prop Facts

Makai Lemon has recorded 10+ receptions in two consecutive games – longest streak in the FBS, heading into Week 13.

Matchup/League Facts

Oregon ranks 1st among FBS teams for average point differential in second quarters this season (+10.6).
Oregon ranks 2nd among FBS teams for Q3 opponent points per game this season (1.7).
USC ranks 6th among FBS teams for average point differential in fourth quarters this season (+5.7).
USC ranks T8th among FBS teams for H2 points per game this season (19.4).

USC vs Oregon Prediction

I’ll just stay with Oregon here. The Ducks beat a pretty decent Minnesota team last Friday—and beat them badly. Oregon had 510 yards in that one with 8.1 yards per play, 27 first downs and a 6-of-9 success rate on third-down tries. Meanwhile the defense gave up just 200 yards on the other side with 3.5 yards per play and 13 first downs. There were no takeaways there but it hardly mattered. Oregon had scored fewer than 22 points in three of their previous four games, so the 42 points were a welcome sight on the scoreboard in the blowout win.

As for USC, they had a scare versus Iowa over the weekend but pulled off the home win thanks to a strong second half. The Trojans finished with 360 yards, 5.7 yards per play, 21 first downs and 5-of-10 on third-down tries. That makes 21 or more points in every game so far for the Trojans. This will be a tough matchup to keep that streak going, but it’ll be a fun one to watch regardless.