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USC vs Notre Dame Prediction 10/18/2025 Today’s College Football Picks

Oct 11, 2025; South Bend, Indiana, USA; Notre Dame Fighting Irish running back Jeremiyah Love (4) runs the ball against the NC State Wolfpack during the second half at Notre Dame Stadium. Mandatory Credit: Michael Caterina-Imagn Images

Oct 11, 2025; South Bend, Indiana, USA; Notre Dame Fighting Irish running back Jeremiyah Love (4) runs the ball against the NC State Wolfpack during the second half at Notre Dame Stadium. Mandatory Credit: Michael Caterina-Imagn Images

MATCHUP USC Trojans Notre Dame Fighting Irish
Team Records 5-2 5-2
Where Notre Dame Stadium, Notre Dame, IN
When Saturday, October 18, 2025
Time 07:30 PM EDT
TV NBC

The USC Trojans and the Notre Dame Fighting Irish meet in week 8 college football action from Notre Dame Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a USC Trojans vs. Notre Dame Fighting Irish prediction.

USC Trojans Recap

The USC Trojans come into this game looking to add on to their win over Michigan by a final score of 31-13 to win to improve to 5-1 this season. After this game, USC will head on the road for a game against Nebraska.

Trojans Looking To Build Momentum

Jayden Maiava has thrown for 1,852 yards, 13 touchdowns and 2 interceptions on 71.9% passing while Husan Longstreet’s thrown for 103 yards and a TD on 86.7% passing. Waymond Jordan leads USC in rushing with 576 yards and 5 TDs while King Miller has 310 rushing yards and 3 touchdowns as well. Eli Sanders has 264 rushing yards and he and the aforementioned Longstreet each have a pair of rushing TDs as well. Makai Lemon leads the Trojans in receiving with 44 catches for 682 yards and 6 touchdowns while Ja’Kobi Lane has 313 receiving yards and 2 TDs and Lake McRee has 289 receiving yards as well as a touchdown. Three more USC receivers have 100+ receiving yards as well this season. On defense, Eric Gentry has a team-high 41 solo tackles while also logging 3 sacks. Bishop Fitzgerald has a team-high 5 interceptions while Devan Thompkins has 3 sacks, Kameryn Crawford has 2.5 sacks and Braylan Shelby has a team-high 3.5 sacks. As a unit, USC has combined for 20 sacks and 8 interceptions so far this season.

Notre Dame Fighting Irish Recap

The Notre Dame Fighting Irish come into this game looking to add on to their 36-7 win over NC State last time out to sit at 4-2 this season. After this game, Notre Dame will head on the road for a game against Boston College.

Irish Win 4 Straight

CJ Carr has thrown for 1,622 yards, 13 touchdowns and 3 interceptions on 66.5% passing while Jeremiyah Love leads the Irish in rushing with 530 rushing yards and 8 touchdowns and Jadarian Price has 422 rushing yards and 7 touchdowns so far this season. Jordan Faison leads Notre Dame in receiving with 29 catches for 376 yards and 2 touchdowns while Eli Raridon has 342 receiving yards and Malachi Fields has 339 receiving yards. Will Pauling’s chipped in 243 receiving yards and 3 TDs as well this seaosn. On defense, Drayk Bowen has a team-high 31 total tackles while Boubacar Traore has a team-high 5.5 sacks. Leonard Moore has a team-high 3 interceptions to lead the Irish. As a unit, Notre Dame’s defense has combined for 15 sacks and 11 interceptions so far this season.

USC Trojans @ Notre Dame Fighting Irish Betting Trends: Week 8

Why the Notre Dame Fighting Irish will win

Why the USC Trojans will win

Total Points Facts

Notre Dame Fighting Irish Player Prop Facts

USC Trojans Player Prop Facts

Matchup/League Facts

USC Trojans vs. Notre Dame Fighting Irish Prediction

I’m on USC here. I just think that this is a ton of points to give up in what could be considered a playoff eliminator. USC has had issues going across time zones in the past, but this USC offense is far too talented to think that they just go down without a whimper here. I think this is going to be a bit of a track meet here so give me USC and the points in this one in a game I could easily see USC winning outright.

Chris Ruffolo's Pick: USC +9.5

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