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UCLA vs USC Prediction 11/29/2025 Today’s College Football Picks

The Oregon defense piles up Southern California running back King Miller during the second half Nov. 22, 2025.

The Oregon defense piles up Southern California running back King Miller during the second half Nov. 22, 2025.

MATCHUP UCLA Bruins USC Trojans
Team Records 3-8 8-3
Spread +22.5 -115 -22.5 -105
Moneyline +1000 -1800
Total Over 58.5 (-118) Under 58.5 (-102)
Where Los Angeles Memorial Coliseum, Los Angeles, CA
When Saturday, November 29, 2025
Time 07:30 PM EST
TV NBC
The UCLA Bruins and USC Trojans meet Saturday in college football action at Los Angeles Memorial Coliseum. Here’s a UCLA vs USC Prediction. This article will include a UCLA vs USC Pick.

UCLA Bruins Betting Preview


The UCLA Bruins lost to Ohio State and Washington. UCLA has lost 4 straight games. Nico Iamaleava is completing 63.5 percent of his passes for 1,728 yards, 12 touchdowns, and 7 interceptions. Kwazi Gilmer and Mikey Matthews have combined for 772 receiving yards and 5 touchdowns, while Titus Mokiao-Atimalala has 21 receptions. The UCLA Bruins ground game is averaging 156.7 yards per contest, and Nico Iamaleava leads the way with 490 yards and 4 touchdowns. Defensively, UCLA is allowing 37.2 points and 425.6 yards per game. JonJon Vaughns leads the UCLA Bruins with 102 tackles, Anthony Jones has 1.5 sacks and Scooter Jackson has 2 interceptions.

USC Trojans Betting Preview


The USC Trojans beat Iowa and lost to Oregon. The USC Trojans have won 3 of their last 4 games. Jayden Maiava is completing 65.7 percent of his passes for 3,174 yards, 21 touchdowns and 8 interceptions. Makai Lemon and Ja’Kobi Lane have combined for 1,817 receiving yards and 14 touchdowns, while Lake McRee has 27 receptions.

The USC Trojans ground game is averaging 196 yards per contest, and King Miller leads the way with 749 yards and 5 touchdowns. Defensively, USC is allowing 25.9 points and 387.7 yards per game. Desman Stephens II leads the USC Trojans with 77 tackles, Braylan Shelby has 3.5 sacks and Bishop Fitzgerald has 5 interceptions.

Why the USC Trojans will win

Why the UCLA Bruins will win

Total Points Facts

USC Trojans Player Prop Facts

UCLA Bruins Player Prop Facts

Matchup/League Facts

UCLA vs USC Prediction


Right when it looked like UCLA had turned the corner, it’s gone back to stinking up the joint on both sides of the ball. UCLA has also covered just 3 games this season. USC should have a field day offensively in this spot against a UCLA defense that’s 94th in total defense and 126th in scoring defense. USC has covered 6 of its last 8 games as a double-digit favorite. Massive line for a rivalry, but UCLA is back in awful form and if that continues, this game won’t be competitive. Give me USC in a home beat down.

Randy Chambers's Pick: USC -22.5

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