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Southern vs Houston Prediction 9/12/2026 Today’s College Football Picks

Oct 25, 2025; Tempe, Arizona, USA; Detailed view of the jersey of Houston Cougars quarterback Conner Weigman (1) against the Arizona State Sun Devils at Mountain America Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images

Oct 25, 2025; Tempe, Arizona, USA; Detailed view of the jersey of Houston Cougars quarterback Conner Weigman (1) against the Arizona State Sun Devils at Mountain America Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images

MATCHUP Southern Jaguars Houston Cougars
Team Records 1-1 1-0
Where TDECU Stadium, Houston, TX
When Saturday, September 12, 2026
Time 07:00 PM EDT
TV ESPN+
In this article we will formulate a Southern vs Houston prediction for this College Football game on Saturday, September 12th at TDECU Stadium in Houston, Texas. Let’s take a look at the prediction for this Week 2 matchup. 

Southern Jaguars Betting Preview

The Southern Jaguars are 1-1 this season after they defeated Kentucky State by a score of 34-15 last week. Southern led 13-2 at halftime and added 21 points in the second half to get the win. The Jaguars were out gained by a total of 378-372, went 4-13 on third downs, and won the turnover battle by a total of 1-0 in the game. Christian Johnson threw for 200 yards and two touchdowns, while Daejawn Smith caught four passes for 72 yards. Trey Holly led the ground game with 21 carries for 99 yards and two scores in the win. 

Prior to that game, Southern lost to Alabama State by a score of 30-17 in week zero. Southern trailed 17-13 at halftime and failed to score in the second half in the loss. The Jaguars were out gained by a total of 351-335, went 4-14 on third downs, and lost the turnover battle by a total of 1-0 in the game. Christian Johnson threw for 174 yards and one interception, while Daejawn Smith caught four passes for 76 yards. Johnson also led the rushing attack with 81 yards and one score on 14 carries. 

Houston Cougars Betting Preview

The Houston Cougars are 1-0 this year after they defeated Oregon State by a score of 33-20 in week one. Houston led 19-7 at halftime, but their lead was cut to 26-20 in the fourth, before they put the game away. The Cougars out gained Oregon State by a total of 533-402, went 7-13 on third downs, and lost the turnover battle by a total of 2-0 in the game. Conner Weigman threw for 305 yards, one touchdown, and one interception, while Amare Thomas caught eight passes for 133 yards and one score. Makhi Hughes rushed 17 times for 98 yards and one touchdown in the win. 

Last year, Houston went 10-3 (6-3) and they finished tied for fourth in the Big 12 standings. Houston started the season with a 27-0 win over SFA and defeated Rice 35-9 in their second game. The Cougars only lost to Texas Tech, TCU, and West Virginia, and they defeated LSU in the Texas Bowl. Houston scored 29.1 points per game in 2025, while they allowed 22.8 points against per game on defense. 

Why the Houston Cougars will win

Why the Southern Jaguars will win

Total Points Facts

Houston Cougars Player Prop Facts

Matchup/League Facts

Southern vs Houston Prediction 

Houston had a little trouble pulling away from Oregon State last week, but they should get a very easy win here. The Cougars have a strong offensive attack and I don’t think Southern will be able to take advantage of their defense. The Jaguars have been out gained in both of their games to start the season and they are going to struggle to find stops. Take Houston to cover at home.

David Racey's Pick: Houston -51.5

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