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Southern Miss vs South Alabama Prediction 11/22/2025 Today’s College Football Picks

South Alabama Jaguars running back Kentrel Bullock (5) runs the ball as Auburn Tigers take on South Alabama Jaguars at Jordan-Hare Stadium in Auburn, Ala. on Saturday, Sept. 13, 2025. Auburn Tigers lead South Alabama Jaguars 28-9 at halftime.

South Alabama Jaguars running back Kentrel Bullock (5) runs the ball as Auburn Tigers take on South Alabama Jaguars at Jordan-Hare Stadium in Auburn, Ala. on Saturday, Sept. 13, 2025. Auburn Tigers lead South Alabama Jaguars 28-9 at halftime.

MATCHUP Southern Mississippi Golden Eagles South Alabama Jaguars
Team Records 5-5-7 3-7
Spread -1.5 -110 +1.5 -110
Moneyline -118 -102
Total Over 53.5 (-108) Under 53.5 (-112)
Where Hancock Whitney Stadium, Mobile, AL
When Saturday, November 22, 2025
Time 03:30 PM EST
TV ESPN+
The Southern Mississippi Golden Eagles and South Alabama Jaguars meet Saturday in college football action at Hancock Whitney Stadium. Here’s a Southern Miss vs South Alabama Prediction. This article will include a Southern Miss vs South Alabama Pick.

Southern Mississippi Golden Eagles Betting Preview


The Southern Mississippi Golden Eagles beat Arkansas State, lost to Texas State, and will play Troy next. Southern Mississippi has won 5 of its last 6 games. Braylon Braxton is completing 67.3 percent of his passes for 2,187 yards, 19 touchdowns, and 5 interceptions. Elijah Metcalf and Tychaun Chapman have combined for 934 receiving yards and 4 touchdowns, while Micah Davis has 26 receptions.

The Southern Mississippi Golden Eagles ground game is averaging 150.8 yards per contest, and Jeffery Pittman leads the way with 548 yards and 7 touchdowns. Defensively, Southern Mississippi is allowing 25.9 points and 395 yards per game. Chris Jones leads the Southern Mississippi Golden Eagles with 106 tackles, J’Mond Tapp has 5.5 sacks and Josh Moten has 5 interceptions.

South Alabama Jaguars Betting Preview


The South Alabama Jaguars lost to Louisiana, beat UL Monroe, and they play Texas State next. South Alabama has lost 7 of its last 9 games. Bishop Davenport is completing 66.8 percent of his passes for 1,826 yards, 12 touchdowns, and 5 interceptions. Devin Voisin and Jeremy Scott have combined for 1,012 receiving yards and 7 touchdowns, while Anthony Eager has 33 receptions.

The South Alabama Jaguars ground game is averaging 194.3 yards per contest, and Kentrel Bullock leads the way with 814 yards and 10 touchdowns. Defensively, South Alabama is allowing 28.1 points and 356.6 yards per game. Darius McKenzie leads the South Alabama Jaguars with 65 tackles, Tyler Thomas has 2 sacks and Nehemiah Chandler has 2 interceptions.

Why the South Alabama Jaguars will win

Why the Southern Miss Golden Eagles will win

Total Points Facts

South Alabama Jaguars Player Prop Facts

Southern Miss Golden Eagles Player Prop Facts

Matchup/League Facts

Southern Miss vs South Alabama Prediction


South Alabama is coming off a nice win over UL Monroe, but it has yet to win back-to-back games this season. Southern Miss has simply been the better team this season by a wide margin, and a top-50 scoring offense should have a field day against this South Alabama defense. South Alabama will be up for this one given its senior day for 21 seniors, but it’s going to take more than that to move the needle. Southern Miss has simple been the more impressive team this season and has a chance to win 8 games for the first time since the 2017 season. I’ll lay the points.

Randy Chambers's Pick: Southern Mississippi -1.5

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