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Rutgers vs Ohio State Prediction 11/22/2025 Today’s College Football Picks

From left to right, R.J. Day, CJ Barnett, wide receiver Jeremiah Smith (4), J.T. Tuimoloau, linebacker C.J. Hicks (11) and running back CJ Donaldson Jr. (12) walk down the tunnel at halftime of the NCAA college football game at Ohio Stadium on Saturday, Nov. 15, 2025 in Columbus, Ohio.

From left to right, R.J. Day, CJ Barnett, wide receiver Jeremiah Smith (4), J.T. Tuimoloau, linebacker C.J. Hicks (11) and running back CJ Donaldson Jr. (12) walk down the tunnel at halftime of the NCAA college football game at Ohio Stadium on Saturday, Nov. 15, 2025 in Columbus, Ohio.

MATCHUP Rutgers Scarlet Knights Ohio State Buckeyes
Team Records 5-5 10-0
Where Ohio Stadium, Columbus, OH
When Saturday, November 22, 2025
Time 12:00 PM EST
TV FOX
The Rutgers Scarlet Knights and Ohio State Buckeyes meet Saturday in college football action at Ohio Stadium. Here’s a Rutgers vs Ohio State Prediction. This article will include a Rutgers vs Ohio State Pick.

Rutgers Scarlet Knights Betting Preview


The Rutgers Scarlet Knights beat Maryland, lost to Illinois, and they play Penn State State next. The Rutgers Scarlet Knights have lost 5 of their last 7 games. Athan Kaliakmanis is completing 62.3 percent of his passes for 2,705 yards, 17 touchdowns, and 7 interceptions. KJ Duff and Ian Strong have combined for 1,639 receiving yards and 11 touchdowns, while DT Sheffield has 40 receptions.

The Rutgers Scarlet Knights ground game is averaging 143.1 yards per contest, and Antwan Raymond leads the way with 1,000 yards and 11 touchdowns. Defensively, Rutgers is allowing 30 points and 425.5 yards per game. Jett Elad leads the Rutgers Scarlet Knights with 59 tackles, Bradley Weaver has 2.5 sacks and Bo Mascoe has 1 interception.

Ohio State Buckeyes Betting Preview


The Ohio State Buckeyes beat UCLA and Purdue, and they play Michigan next. The Ohio State Buckeyes have won 14 straight games. Julian Sayin is completing 80.1 percent of his passes for 2,675 yards, 25 touchdowns, and 4 interceptions. Jeremiah Smith and Carnell Tate have combined for 1,613 receiving yards and 17 touchdowns, while Max Klare has 31 receptions.

The Ohio State Buckeyes ground game is averaging 161.8 yards per contest, and Bo Jackson leads the way with 725 yards and 3 touchdowns. Defensively, Ohio State is allowing 7.5 points and 212.6 yards per game. Arvell Reese leads the Ohio State Buckeyes with 58 tackles, Caden Curry has 7 sacks and Jermaine Mathews Jr. has 2 interceptions.

Why the Ohio State Buckeyes will win

Why the Rutgers Scarlet Knights will win

Total Points Facts

Ohio State Buckeyes Player Prop Facts

Rutgers Scarlet Knights Player Prop Facts

Matchup/League Facts

Rutgers vs Ohio State Prediction


Rutgers needs one more win to become bowl eligible, so I don’t expect this team to just rollover. However, Rutgers doesn’t play a lick of defense, and that’s not ideal going up against the Buckeyes. Ohio State is arguably the best team in the country and is 8-1-1 ATS on the season. Ohio State is 4-1-1 ATS this season when favorites of 20 or more points, and it’s winning those games by an average of 38.5 points. Thick number, but Rutgers isn’t the team you pick to step in front of the freight train that is Ohio State.

Randy Chambers's Pick: Ohio State -31.5

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