Pittsburgh (6-2) vs Stanford (3-5)
November 1, 2025 at 03:30 PM EDT
The Line: Betting Odds: Stanford +14.5 — Over/Under: +51.5
The Pitt Panthers and the Stanford Cardinal meet in week 10 college football action from Stanford Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Pitt Panthers vs. Stanford Cardinal prediction.
Pitt Panthers Recap
The Pitt Panthers come into this game looking to add on to their 53-34 win over NC State last time out to sit at 6-2 this season. After this game, Pitt will head home for a game against Notre Dame.
Panthers Win 4th In A Row
Eli Holstein has thrown for 1,058 yards, 11 touchdowns and 5 interceptions on 62.7% passing while Mason Heintschel has 1,243 passing yards, 9 touchdowns and 3 interceptions on 65.1% passing. Ja’Kyrian Turner leads Pitt with 272 rushing yards and 6 TDs while Desmond Reid has 266 rushing yards and 2 TDs and Juelz Goff has 192 yards and 4 TDs. Kenny Johnson leads Pitt’s receiving group with 33 grabs for 502 yards and 3 TDs while Raphael Williams has 488 receiving yards with 5 TDs. Cataurus Hicks has 336 receiving yards with 4 TDs and the aforementioned Reid has 254 receiving yards as well this season. On defense, Rasheem Biles leads Pitt with 52 total tackles along with a pair of sacks while Kyle Louis has a pair of sacks as well. As a unit, Pitt’s defense has combined for 19 sacks and 7 interceptions so far this season.
Stanford Cardinal Recap
The Stanford Cardinal come into this game looking to bounce back from a 42-7 loss at the hands of Miami last time out to sit at 3-5 this season. After this game, Stanford will head on the road for a game against the North Carolina Tar Heels.
Cardinal Alternate Wins & Losses In 7 Straight
Ben Gulbranson has thrown for 1,585 yards, 8 touchdowns and 7 interceptions on 57% passing while Micah Ford leads the Cardinal in rushing with 425 yards and 3 TDs and Cole Tabb has 376 rushing yards as well this season. CJ Williams has 40 receptions for 476 receiving yards and 2 TDs while Bryce Farrell has 400 receiving yards as well this season. Sam Roush has 305 receiving yards while Caden High has 255 receiving yards as well on the year. On defense, Matt Rose has a team-high 68 total tackles including 31 solo tackles while Clay Patterson has a team-high 3 sacks and Stanford’s defense as a whole has combined for 14 sacks and an interception so far this season.
Pittsburgh Panthers @ Stanford Cardinal Betting Trends: Week 10
Why the Stanford Cardinal will win
- The home team has won each of Stanford’s last 12 games.
- Pittsburgh has lost each of its last six games in November.
- The home team has covered the spread in eight of Stanford’s last nine games.
- Pittsburgh has failed to cover the spread in each of its last four November games against non-AP-ranked teams.
- Stanford has won the first quarter in each of its last three home games against conference opponents.
- Pittsburgh has lost the first half in four of its last five road games against conference opponents.
Why the Pittsburgh Panthers will win
- Stanford has lost each of its last seven November home games against non-AP-ranked teams.
- Pittsburgh has won each of its last four games.
- Stanford has failed to cover the spread in each of its last seven November home games against non-AP-ranked teams.
- Pittsburgh has covered the spread in each of its last four games.
- Stanford has lost the first half in eight of its last 10 home games against conference opponents.
Total Points Facts
- Eleven of Stanford’s last 12 home games in November have gone OVER the total points line.
Stanford Cardinal Player Prop Facts
- Heading into Week 10, Micah Ford leads Stanford for touchdowns (3) this season.
Pittsburgh Panthers Player Prop Facts
- Heading into Week 10, Trey Butkowski ranks 2nd amongst FBS players for made field goals (19) this season.
Matchup/League Facts
- Stanford has recorded the equal-most home wins by a margin of 10 points or less of any FBS team this season (3).
- Stanford has suffered the equal-most road losses by a margin of 10+ points of any FBS team this season (4).
- Pittsburgh ranks 3rd among FBS teams for Q2 points per game this season (13.6).
- Pittsburgh ranks 8th among FBS teams for points per game this season (40.3).
Pitt Panthers vs. Stanford Cardinal Prediction
I’m leaning towards Stanford and the points in this one. I just have my concerns about this Pitt defense, and we’ve seen teams make the cross country trip have trouble adjusting. Stanford’s 3-0 at home this season, and while the losses haven’t been stellar, it’s worth remembering they came against Miami, SMU and Virginia, three of the better teams in the ACC, and a game against BYU that they were simply overmatched in as well as a road game against Hawaii that they lost in walk-off fashion on opening night. Pitt’s offense is better but they’ve let some teams hang around offensively and I think Stanford could here as well. Give me the Cardinal and the points.