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Penn State vs Clemson Prediction 12/27/2025 Today’s College Football Picks

Clemson running back Adam Randall (8) scores a two-point conversion against South Carolina during the fourth quarter at Williams-Brice Stadium in Columbia, S.C. Saturday, November 29, 2025.

Clemson running back Adam Randall (8) scores a two-point conversion against South Carolina during the fourth quarter at Williams-Brice Stadium in Columbia, S.C. Saturday, November 29, 2025.

MATCHUP Penn State Nittany Lions Clemson Tigers
Team Records 6-6 7-5
Spread +3 -120 -3 100
Moneyline +124 -148
Total Over 47.5 (-115) Under 47.5 (-105)
Where Yankee Stadium, Bronx, NY
When Saturday, December 27, 2025
Time 12:00 PM EST
TV ABC
The Penn State Nittany Lions and Clemson Tigers meet Friday in the college football Pinstripe Bowl at Yankee Stadium. Here’s a Penn State vs Clemson Prediction. This article will include a Penn State vs Clemson Pick.

Penn State Nittany Lions Betting Preview


The Penn State Nittany Lions beat Nebraska and Rutgers. Penn State has won 3 straight games. Ethan Grunkemeyer is completing 69.4 percent of his passes for 1,079 yards, 6 touchdowns, and 4 interceptions. Devonte Ross and Trebor Pena have combined for 869 receiving yards and 6 touchdowns, while Kyron Hudson has 23 receptions.

The Penn State Nittany Lions ground game is averaging 177.5 yards per contest, and Kaytron Allen leads the way with 1,303 yards and 15 touchdowns. Defensively, Penn State is allowing 21.4 points and 334.3 yards per game. Amare Campbell leads the Penn State Nittany Lions with 96 tackles, Dani Dennis-Sutton has 6.5 sacks and Alonzo Ford Jr. has 1 interception.

Clemson Tigers Betting Preview


The Clemson Tigers beat Furman and South Carolina. Clemson has won 4 straight games. Cade Klubnik is completing 66.6 percent of his passes for 2,750 yards, 16 touchdowns, and 6 interceptions. Antonio Williams and T.J. Moore have combined for 1,358 receiving yards and 8 touchdowns, while Bryant Wesco Jr. has 31 receptions.

The Clemson Tigers ground game is averaging 131.3 yards per contest, and Adam Randall leads the way with 779 yards and 9 touchdowns. Defensively, Clemson is allowing 20.4 points and 353.8 yards per game. Sammy Brown leads the Clemson Tigers with 91 tackles, Will Heldt has 7.5 sacks and Ricardo Jones has 6 interceptions.

Why the Clemson Tigers will win

Why the Penn State Nittany Lions will win

Total Points Facts

Clemson Tigers Player Prop Facts

Penn State Nittany Lions Player Prop Facts

Matchup/League Facts

Penn State vs Clemson Prediction


Penn State and Clemson ended the season on a high note, so neither of these teams have quit. Could be a good one. Clemson is probably the more talented team, but it will be without a few key defenders and wide receiver Antonio Williams. Penn State won’t have a couple of offensive linemen and running back Nicholas Singleton. Still, Penn State seems to be a bit more whole roster wise, and this should be a very pro Nittany Lions crowd with the game in New York. Clemson was inconsistent offensively with a poor rushing attack, and not having one of its best weapons won’t make things better. Clemson is 4-12 ATS in its last 16 games as a favorite. Give me the points with Penn State.

Randy Chambers's Pick: Penn State +2.5

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