Oregon vs Northwestern Prediction 9/13/2025 Today’s College Football Picks

In this article we will formulate an Oregon vs Northwestern prediction for this College Football game on Saturday, September 13th at Northwestern Medicine Field at Martin Stadium in Evanston, Illinois. Let’s take a look at the prediction for this week 3 matchup. 

Oregon Ducks Betting Preview

The Oregon Ducks are 2-0 (0-0) this season after they defeated Oklahoma State by a score of 69-3 in their last game. Oregon led 20-0 after the first quarter and they stretched it to 41-3 at the half. The Ducks poured it on in the third quarter, before cruising to the win in the fourth. Oregon out gained OSU by a total of 631-211, went 7-12 on third downs, and won the turnover battle by a total of 2-0. Dante Moore went 16-21 for 266 yards and three touchdowns, while Jeremiah McClellan caught two passes for 76 yards. Noah Whittington rushed for 91 yards and one touchdown on four carries to lead the rushing attack. 

Oregon won their week one game by a score of 59-13 over Montana State, who is in the FCS. The Ducks are averaging 63.0 points per game with 286 passing yards and 282.5 rushing yards per game, while they are allowing 8.0 points against per game this season. Dante Moore has completed 77.3% of his passes for 479 yards and six touchdowns, while Noah Whittington has rushed for 159 yards and two scores. Malik Benson has caught seven passes for 99 yards and two touchdowns to lead the receivers this season. 

Northwestern Wildcats Betting Preview

The Northwestern Wildcats are 1-1 this year after they defeated Western Illinois by a score of 42-7 last week. Northwestern led 22-0 at halftime and added 20 more points in the second half, but did lose the shutout late in the fourth. The Wildcats out gained WIU by a total of 526-181, went 8-16 on third downs, and tied the turnover battle at one. Preston Stone went 21-29 for 245 yards and three touchdowns, while Cam Porter rushed 12 times for 91 yards and one score. Griffin Wilde caught five passes for 94 yards in the win to lead the receivers. 

Northwestern started the 2025 season with a bad loss against Tulane by a score of 23-3. The Wildcats are averaging 22.5 points per game with 203.0 passing yards and 178.5 rushing yards per game, while they are allowing 15.0 points against per game this season. Preston Stone has completed 61.5% of his passes for 406 yards, three touchdowns, and four interceptions, while Griffin Wilde has caught 11 passes for 158 yards this year. Cam Porter has led the rushing attack with 137 yards and one touchdown on 18 carries.

Why Oregon will beat Northwestern

Oregon has won each of its last 20 September games against non-AP-ranked teams.
Northwestern has lost each of its last 11 games as an underdog against AP-ranked teams.
Oregon has covered the spread in each of its last five road openers as a favorite.
Northwestern has failed to cover the spread in four of its last five games against AP-ranked teams.

Total Points Facts

Each of Oregon’s last four games as a favorite have gone OVER the total points line.
Six of Northwestern’s last seven games as an underdog against top-15 AP-ranked teams have gone UNDER the total points line.

Matchup/League Facts

Northwestern ranks T114th among FBS teams for Q3 points per game this season (3.0).
Northwestern ranks T114th among FBS teams for 4th down conversion percentage against this season (100.0).
Oregon ranks 1st among FBS teams for average point differential in third quarters this season (+19.5).
Oregon ranks T1st among FBS teams for red zone percentage this season (100.0). 

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Oregon vs Northwestern Prediction 

Northwestern comes into this matchup after picking up an easy win against a FCS team last week, but they are still looking for their first FBS win this year. The Wildcats played horribly on the offensive side of the ball against Tulane and turnovers were a big issue. Oregon has dominated their first two games and just beat Oklahoma State by a score of 69-3. The Ducks should control this game from start to finish and I just don’t see how the NW offense can hang around. I don’t trust Stone throwing the ball against this Oregon defense and I expect a few more turnovers from him. Take the Ducks to cover on the road, while also taking a look at their team total.