Oklahoma State (1-3) vs Arizona (3-1)
October 4, 2025 at 03:00 PM EDT
The Line: Betting Odds: Arizona -20.5 — Over/Under: +56.5
In this article, we will formulate an Oklahoma State vs Arizona Prediction for this College Football Week 6 game on Saturday, October 4th at the Arizona Stadium. Let’s take a look at the prediction for this College Football matchup.
Offensively, the Wildcats average 31.2 points per game, which ranks 59th in the nation. Defensively, they allow 16.2 points per game, which is 25th. Arizona averages 418 total yards per game, with 168.5 rushing yards and 249.5 passing yards per game. They allow 266.5 total yards per game, with 99.8 rushing and 166.8 passing yards per game.
Noah Fifita leads the Wildcats with 965 passing yards and 61.9% completed passes. Ismail Mahdi leads the team in rushing yards, with 348, while Javin Whatley has a team-high 17 caught passes for 264 receiving yards, and has 2 touchdowns. Defensively, Dalton Johnson has a team-high 26 total tackles, 14 of them solo. Chase Kennedy leads the Wildcats in sacks, with 2, while Genesis Smith has one interception.
Offensively, the Cowboys average 17.2 points per game, which ranks 124th in the nation. Defensively, they allow 35.0 points per game, which is 126th. Oklahoma State averages 355.3 total yards per game, with 153.3 rushing yards and 202 passing yards per game. They allow 473 total yards per game, with 213 rushing and 260 passing yards per game.
Zane Flores leads the Cowboys with 649 passing yards and 56.7% completed passes. Rodney Fields Jr. leads the team in rushing yards, with 182, while Shamar Rigby has a team-high 10 caught passes for 150 receiving yards. Defensively, Bryan McCoy has a team-high 36 total tackles, 13 of them solo. Wendell Gregory leads the Cowboys in sacks, with 3, while Kale Smith has one interception.
In this Oklahoma State vs Arizona Prediction, Arizona is coming as -20-point home favorites, with the total set at 55.5 points. Arizona has been the far better team this season, and want to bounce back after their first defeat of the season. They have won and covered both of their home games this season, while Oklahoma State has lost and failed to cover their only road game. The Wildcats have the 25th-best defense in the nation, while the Cowboys have the 7th-worst defense. Take Arizona and lay the points at home for an easy win.
Arizona Preview
Arizona has a 3-1 record this season and is sitting on the 11th place of the Big 12. They are 3-1 ATS, 1-3 in Over/Under and have a 3-0 home record and 0-1 away record. The Wildcats are coming off a 14-39 road loss in Iowa State and are playing BYU and Houston next.Offensively, the Wildcats average 31.2 points per game, which ranks 59th in the nation. Defensively, they allow 16.2 points per game, which is 25th. Arizona averages 418 total yards per game, with 168.5 rushing yards and 249.5 passing yards per game. They allow 266.5 total yards per game, with 99.8 rushing and 166.8 passing yards per game.
Noah Fifita leads the Wildcats with 965 passing yards and 61.9% completed passes. Ismail Mahdi leads the team in rushing yards, with 348, while Javin Whatley has a team-high 17 caught passes for 264 receiving yards, and has 2 touchdowns. Defensively, Dalton Johnson has a team-high 26 total tackles, 14 of them solo. Chase Kennedy leads the Wildcats in sacks, with 2, while Genesis Smith has one interception.
Oklahoma State Preview
Oklahoma State has a 1-3 record this season and is sitting on the 14th place of the Big 12. They are 1-3 ATS, 2-2 in Over/Under and have a 1-2 home record and 0-1 away record. The Cowboys are coming off a 27-45 home loss against Baylor and are playing Houston and Cincinnati next.Offensively, the Cowboys average 17.2 points per game, which ranks 124th in the nation. Defensively, they allow 35.0 points per game, which is 126th. Oklahoma State averages 355.3 total yards per game, with 153.3 rushing yards and 202 passing yards per game. They allow 473 total yards per game, with 213 rushing and 260 passing yards per game.
Zane Flores leads the Cowboys with 649 passing yards and 56.7% completed passes. Rodney Fields Jr. leads the team in rushing yards, with 182, while Shamar Rigby has a team-high 10 caught passes for 150 receiving yards. Defensively, Bryan McCoy has a team-high 36 total tackles, 13 of them solo. Wendell Gregory leads the Cowboys in sacks, with 3, while Kale Smith has one interception.
Oklahoma State Cowboys @ Arizona Wildcats Betting Trends: Week 6
Why the Arizona Wildcats will win
- Oklahoma State has lost each of its last 11 games against conference opponents.
- The home team has won seven of Arizona’s last eight games.
- Oklahoma State has failed to cover the spread in eight of its last nine games.
- The home team has covered the spread in seven of Arizona’s last eight games.
- Oklahoma State has lost the first half in each of its last five games against conference opponents.
Why the Oklahoma State Cowboys will win
- Arizona has lost four of its last five October games as a home favorite against non-AP-ranked teams.
- Oklahoma State has won 10 of its last 15 October games as an underdog.
- Oklahoma State has covered the spread in 13 of its last 15 October games as an underdog.
- Arizona has failed to cover the spread in five of its last six October games as a favorite against non-AP-ranked teams.
- Arizona has lost the first half in eight of its last 10 games against conference opponents.
Total Points Facts
- Seven of Arizona’s last eight home games against non-AP-ranked teams have gone UNDER the total points line.
- Each of Oklahoma State’s last four October games as an underdog have gone OVER the total points line.
Arizona Wildcats Player Prop Facts
- Heading into Week 6, Noah Fifita leads Arizona for touchdowns (3) this season.
Oklahoma State Cowboys Player Prop Facts
- Heading into Week 6, Zane Flores has the most pass attempts without a passing touchdown this season (120).
Matchup/League Facts
- Arizona ranks T1st among FBS teams for Q4 opponent points per game this season (1.5).
- Arizona ranks 129th among FBS teams for Q4 points per game this season (3.0).
- Oklahoma State ranks T133rd among FBS teams for H1 opponent points per game this season (23.0).
- Oklahoma State ranks 133rd among FBS teams for average point differential in second quarters this season (-7.3).
Oklahoma State vs Arizona Prediction
In their previous meeting back in 2012, Arizona won 59-38 at home, but Oklahoma State has won their previous two meetings.In this Oklahoma State vs Arizona Prediction, Arizona is coming as -20-point home favorites, with the total set at 55.5 points. Arizona has been the far better team this season, and want to bounce back after their first defeat of the season. They have won and covered both of their home games this season, while Oklahoma State has lost and failed to cover their only road game. The Wildcats have the 25th-best defense in the nation, while the Cowboys have the 7th-worst defense. Take Arizona and lay the points at home for an easy win.