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Oklahoma State vs Arizona Prediction 10/4/2025 Today’s College Football Picks

Nov 4, 2023; Tucson, Arizona, USA; Arizona Wildcats wide receiver Montana Lemonious-Craig #5 dives into the endzone against UCLA Bruins defensive back Jaylin Davies #24 and defensive lineman Laiatu Latu #15  during the first half at Arizona Stadium. Mandatory Credit: Zachary BonDurant-Imagn Images

Nov 4, 2023; Tucson, Arizona, USA; Arizona Wildcats wide receiver Montana Lemonious-Craig #5 dives into the endzone against UCLA Bruins defensive back Jaylin Davies #24 and defensive lineman Laiatu Latu #15 during the first half at Arizona Stadium. Mandatory Credit: Zachary BonDurant-Imagn Images

MATCHUP Oklahoma State Cowboys Arizona Wildcats
Team Records 1-4 4-1
Where Arizona Stadium, Tucson, AZ
When Saturday, October 4, 2025
Time 03:00 PM EDT
TV TNT

In this article, we will formulate an Oklahoma State vs Arizona Prediction for this College Football Week 6 game on Saturday, October 4th at the Arizona Stadium. Let’s take a look at the prediction for this College Football matchup.

Arizona Preview

Arizona has a 3-1 record this season and is sitting on the 11th place of the Big 12. They are 3-1 ATS, 1-3 in Over/Under and have a 3-0 home record and 0-1 away record. The Wildcats are coming off a 14-39 road loss in Iowa State and are playing BYU and Houston next.

Offensively, the Wildcats average 31.2 points per game, which ranks 59th in the nation. Defensively, they allow 16.2 points per game, which is 25th. Arizona averages 418 total yards per game, with 168.5 rushing yards and 249.5 passing yards per game. They allow 266.5 total yards per game, with 99.8 rushing and 166.8 passing yards per game.

Noah Fifita leads the Wildcats with 965 passing yards and 61.9% completed passes. Ismail Mahdi leads the team in rushing yards, with 348, while Javin Whatley has a team-high 17 caught passes for 264 receiving yards, and has 2 touchdowns. Defensively, Dalton Johnson has a team-high 26 total tackles, 14 of them solo. Chase Kennedy leads the Wildcats in sacks, with 2, while Genesis Smith has one interception.

Oklahoma State Preview

Oklahoma State has a 1-3 record this season and is sitting on the 14th place of the Big 12. They are 1-3 ATS, 2-2 in Over/Under and have a 1-2 home record and 0-1 away record. The Cowboys are coming off a 27-45 home loss against Baylor and are playing Houston and Cincinnati next.

Offensively, the Cowboys average 17.2 points per game, which ranks 124th in the nation. Defensively, they allow 35.0 points per game, which is 126th. Oklahoma State averages 355.3 total yards per game, with 153.3 rushing yards and 202 passing yards per game. They allow 473 total yards per game, with 213 rushing and 260 passing yards per game.

Zane Flores leads the Cowboys with 649 passing yards and 56.7% completed passes. Rodney Fields Jr. leads the team in rushing yards, with 182, while Shamar Rigby has a team-high 10 caught passes for 150 receiving yards. Defensively, Bryan McCoy has a team-high 36 total tackles, 13 of them solo. Wendell Gregory leads the Cowboys in sacks, with 3, while Kale Smith has one interception.

Oklahoma State Cowboys @ Arizona Wildcats Betting Trends: Week 6

Why the Arizona Wildcats will win

Why the Oklahoma State Cowboys will win

Total Points Facts

Arizona Wildcats Player Prop Facts

Oklahoma State Cowboys Player Prop Facts

Matchup/League Facts

Oklahoma State vs Arizona Prediction

In their previous meeting back in 2012, Arizona won 59-38 at home, but Oklahoma State has won their previous two meetings.

In this Oklahoma State vs Arizona Prediction, Arizona is coming as -20-point home favorites, with the total set at 55.5 points. Arizona has been the far better team this season, and want to bounce back after their first defeat of the season. They have won and covered both of their home games this season, while Oklahoma State has lost and failed to cover their only road game. The Wildcats have the 25th-best defense in the nation, while the Cowboys have the 7th-worst defense. Take Arizona and lay the points at home for an easy win.

Nikos Lagouretos's Pick: Arizona -20.5

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