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Ohio State vs Washington Prediction 9/27/2025 Today’s College Football Picks

Sep 6, 2025; Seattle, Washington, USA; Washington Huskies running back Jonah Coleman (1) returns to the locker room following a victory against the UC Davis Aggies at Husky Stadium. Mandatory Credit: Joe Nicholson-Imagn Images

Sep 6, 2025; Seattle, Washington, USA; Washington Huskies running back Jonah Coleman (1) returns to the locker room following a victory against the UC Davis Aggies at Husky Stadium. Mandatory Credit: Joe Nicholson-Imagn Images

Ohio State (3-0) vs Washington (3-0)

September 27, 2025 at 03:30 PM EDT

The Line: Betting Odds: Washington +8.5 — Over/Under: +52.5

(Get latest betting odds)

The Ohio State Buckeyes and Washington Huskies meet Saturday in college football action at Husky Stadium. Here’s a Ohio State vs Washington Prediction. This article will include a Ohio State vs Washington Pick.

Ohio State Buckeyes Betting Preview


The Ohio State Buckeyes beat Grambling and Ohio, and they play Minnesota next. The Ohio State Buckeyes have won 7 straight games. Julian Sayin is completing 78.9 percent of his passes for 779 yards, 8 touchdowns, and 3 interceptions. Jeremiah Smith and Carnell Tate have combined for 534 receiving yards and 6 touchdowns, while Will Kacmarek has 4 receptions.

The Ohio State Buckeyes ground game is averaging 192 yards per contest, and Bo Jackson leads the way with 217 yards and 1 touchdown. Defensively, Ohio State is allowing 5.3 points and 227.7 yards per game. Arvell Reese leads the Ohio State Buckeyes with 20 tackles, Caden Curry has 2 sacks and Jermaine Mathews Jr. has 1 interception.

Washington Huskies Betting Preview


The Washington Huskies beat UC Davis and Washington State, and they play Maryland next. The Washington Huskies have split their last 12 games. Demond Williams Jr. is completing 73.5 percent of his passes for 778 yards, 6 touchdowns, and 0 interceptions. Denzel Boston and Jonah Coleman have combined for 399 receiving yards and 4 touchdowns, while Dezman Roebuck has 6 receptions.

The Washington Huskies ground game is averaging 260 yards per contest, and Jonah Coleman leads the way with 347 yards and 9 touchdowns. Defensively, Washington is allowing 18.3 points and 262.3 yards per game. Deven Bryant leads the Washington Huskies with 17 tackles, Isaiah Ward has 1.5 sacks and Alex McLaughlin has 2 interceptions.

Ohio State Buckeyes @ Washington Huskies Betting Trends: Week 5


Why the Washington Huskies will win

  • Washington has won each of its last 13 games against conference opponents at Husky Stadium.
  • Washington has covered the spread in each of its last four games against conference opponents at Husky Stadium.
  • Ohio State has failed to cover the spread in three of its last four games against non-AP-ranked teams.

Why the Ohio State Buckeyes will win

  • Ohio State has won each of its last 19 road games against non-AP-ranked teams.
  • Washington has lost four of its last five games against AP-ranked teams.
  • Washington has failed to cover the spread in each of its last four games as an underdog against top-15 AP-ranked teams.
  • Ohio State has covered the spread in six of its last seven games as a favorite.

Total Points Facts

  • Each of Washington’s last six games have gone OVER the total points line.
  • Seven of Ohio State’s last eight games as a favorite against non-AP-ranked teams have gone UNDER the total points line.

Washington Huskies Player Prop Facts

  • Heading into Week 5, Jonah Coleman ranks 1st amongst FBS players for rushing touchdowns (9) this season.

Ohio State Buckeyes Player Prop Facts

  • Heading into Week 5, Julian Sayin ranks 7th amongst qualified players for sack percentage (1.4%) this season.

Matchup/League Facts

  • Washington ranks 1st among FBS teams for H2 points per game this season (29.0).
  • Washington ranks 1st among FBS teams for average point differential in fourth quarters this season (+17.3).
  • Ohio State ranks T2nd among FBS teams for H1 opponent points per game this season (1.0).
  • Ohio State ranks 3rd among FBS teams for 1st downs against this season (35).

Ohio State vs Washington Prediction


Washington is off to a fine start with an underrated defense and an offense that’s top-10 in both total offense and scoring offense. The problem is Washington hasn’t played anybody up to this point, so the jury is still out on what’s real and what isn’t. Washington has failed to cover 6 of its last 7 games as an underdog. Ohio State is 7-3-1 ATS in its last 11 games when favorites of 7 or more points. Also, Ohio State has had an extra week to prepare for this game. It’s hard to turn down the better team that also has the rest advantage. I expect Ohio State to make a statement and get a big road win by double digits.

Randy Chambers's Pick: Ohio State -9

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