Ohio State (5-0) vs Illinois (5-1)
October 11, 2025 at 12:00 PM EDT
The Line: Betting Odds: Illinois +14 — Over/Under: +50
In this article we will formulate an Ohio State vs Illinois prediction for this College Football game on Saturday, October 11th at Memorial Stadium in Champaign, Illinois. Let’s take a look at the prediction for this week 7 matchup.
Prior to that win, Ohio State defeated Washington, Ohio, Grambling, and Texas to start the season undefeated. The Buckeyes are averaging 37.4 points per game with 279.8 passing yards and 171.6 rushing yards per game, while they are allowing 5.0 points against per game this season. Julian Sayin has completed 80.2% of his passes for 1,313 yards, 13 touchdowns, and three interceptions, while Jeremiah Smith has 35 receptions for 463 yards and six scores. Bo Jackson has led the rushing attack with 48 carries for 360 yards and two touchdowns this season.
Prior to that game, Illinois defeated USC, Western Michigan, Duke, and Western Illinois, but did lose to Indiana by a score of 63-10 a few weeks ago. The Fighting Illini are averaging 37.0 points per game with 267.2 passing yards and 130.7 rushing yards per game, while they are allowing 24.0 points against per game this season. Luke Altmyer has completed 73.6% of his passes for 1,573 yards, 12 touchdowns, and zero interceptions, while Hank Beatty has 32 receptions for 569 yards and two scores. Ca’Lil Valentine has led the ground game with 61 carries for 323 yards and three touchdowns this year.
Illinois has covered the spread in each of its last five games in Illinois.
Ohio State has failed to cover the spread in three of its last four October games as a road favorite.
Ohio State has covered the spread in each of its last seven games as a favorite against AP-ranked teams.
Illinois has failed to cover the spread in nine of its last 12 games against conference opponents at Gies Memorial Stadium.
Six of Ohio State’s last eight games in October have gone UNDER the total points line.
Illinois ranks 129th among FBS teams for 1st downs against this season (129).
Ohio State has recorded the equal-most home wins by a margin of 20+ points of any FBS team this season (3).
Ohio State has recorded the equal-most home wins by a margin of 25+ points of any FBS team this season (3).
David Racey is 58-44 (57%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!
Ohio State Buckeyes Betting Preview
The Ohio State Buckeyes are 5-0 (2-0) this season after they defeated Minnesota by a score of 42-3 in their last game. Ohio State led 21-3 at halftime and pitched a shutout in the second half for the blowout victory. The Buckeyes out gained Minnesota by a total of 474-162, went 7-10 on third downs, and tied the turnover battle at zero in the game. Julian Sayin went 23-27 for 326 yards and three touchdowns, while Bo Jackson rushed 13 times for 63 yards and one score. Carnell Tate led the receivers with nine receptions for 183 yards and one touchdown in the win. The OSU defense recorded one sack and seven tackles for loss in the game.Prior to that win, Ohio State defeated Washington, Ohio, Grambling, and Texas to start the season undefeated. The Buckeyes are averaging 37.4 points per game with 279.8 passing yards and 171.6 rushing yards per game, while they are allowing 5.0 points against per game this season. Julian Sayin has completed 80.2% of his passes for 1,313 yards, 13 touchdowns, and three interceptions, while Jeremiah Smith has 35 receptions for 463 yards and six scores. Bo Jackson has led the rushing attack with 48 carries for 360 yards and two touchdowns this season.
Illinois Fighting Illini Betting Preview
The Illinois Fighting Illini are 5-1 (2-1) this year after they defeated Purdue by a score of 43-27 last week. Illinois led 27-14 at halftime and added 16 more points in the second half to seal the victory. The Fighting Illini out gained Purdue by a total of 507-453, went 2-11 on third downs, and won the turnover battle by a margin of 2-0 in the game. Luke Altmyer went 19-22 for 390 yards and one touchdown, while Ca’Lil Valentine rushed 22 times for 95 yards and one score. Hank Beatty led the receivers with five receptions for 186 yards and one touchdown in the game. The Illinois defense recorded two sacks and four tackles for loss in the win.Prior to that game, Illinois defeated USC, Western Michigan, Duke, and Western Illinois, but did lose to Indiana by a score of 63-10 a few weeks ago. The Fighting Illini are averaging 37.0 points per game with 267.2 passing yards and 130.7 rushing yards per game, while they are allowing 24.0 points against per game this season. Luke Altmyer has completed 73.6% of his passes for 1,573 yards, 12 touchdowns, and zero interceptions, while Hank Beatty has 32 receptions for 569 yards and two scores. Ca’Lil Valentine has led the ground game with 61 carries for 323 yards and three touchdowns this year.
Why the Illinois Fighting Illini will win
Illinois has won nine of its last 10 games.Illinois has covered the spread in each of its last five games in Illinois.
Ohio State has failed to cover the spread in three of its last four October games as a road favorite.
Why the Ohio State Buckeyes will win
Ohio State has won each of its last nine games.Ohio State has covered the spread in each of its last seven games as a favorite against AP-ranked teams.
Illinois has failed to cover the spread in nine of its last 12 games against conference opponents at Gies Memorial Stadium.
Total Points Facts
Each of Illinois’ last seven games as an underdog against top-15 AP-ranked teams have gone UNDER the total points line.Six of Ohio State’s last eight games in October have gone UNDER the total points line.
Matchup/League Facts
Illinois ranks T5th among FBS teams for 4th down conversion percentage this season (83.3).Illinois ranks 129th among FBS teams for 1st downs against this season (129).
Ohio State has recorded the equal-most home wins by a margin of 20+ points of any FBS team this season (3).
Ohio State has recorded the equal-most home wins by a margin of 25+ points of any FBS team this season (3).
Ohio State vs Illinois Prediction
Ohio State comes into this contest with an undefeated record and they have allowed nine points or fewer in all of their games so far this year. The Buckeyes have been elite on both sides of the ball, but will face an Illinois offense that is very high scoring. The Fighting Illini have scored 34+ points in four of their last five games, but their defense has allowed 27+ in three straight. The OSU defense has been rock solid, but I think Illinois will be able to score 20+ here. Take the over in this matchup.David Racey is 58-44 (57%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!