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Notre Dame vs Pittsburgh Prediction 11/15/2025 Today’s College Football Picks

Oct 25, 2025; Pittsburgh, Pennsylvania, USA;  Pittsburgh Panthers wide receiver Cataurus Hicks (3) catches a pass and runs for a touchdown against the North Carolina State Wolfpack during the third quarter at Acrisure Stadium. Mandatory Credit: Charles LeClaire-Imagn Images

Oct 25, 2025; Pittsburgh, Pennsylvania, USA; Pittsburgh Panthers wide receiver Cataurus Hicks (3) catches a pass and runs for a touchdown against the North Carolina State Wolfpack during the third quarter at Acrisure Stadium. Mandatory Credit: Charles LeClaire-Imagn Images

MATCHUP Notre Dame Fighting Irish Pittsburgh Panthers
Team Records 7-2 7-2
Spread -12.5 -112 +12.5 -108
Moneyline -455 +350
Total Over 54.5 (-108) Under 54.5 (-112)
Where Acrisure Stadium, Pittsburgh, PA
When Saturday, November 15, 2025
Time 12:00 PM EST
TV ABC
The Notre Dame Fighting Irish and Pittsburgh Panthers meet Saturday in college football action at Acrisure Stadium. Here’s a Notre Dame vs Pittsburgh Prediction. This article will include a Notre Dame vs Pittsburgh Pick.

Notre Dame Fighting Irish Betting Preview


The Notre Dame Fighting Irish beat Boston College and Navy, and play Syracuse next. The Notre Dame Fighting Irish have won 7 straight games. CJ Carr is completing 67.6 percent of his passes for 2,275 yards, 19 touchdowns, and 4 interceptions. Jordan Faison and Malachi Fields have combined for 1,042 receiving yards and 6 touchdowns, while Eli Raridon has 24 receptions.

The Notre Dame Fighting Irish ground game is averaging 194.4 yards per contest, and Jeremiyah Love leads the way with 988 yards and 13 touchdowns. Defensively, Notre Dame is allowing 18.8 points and 334.9 yards per game. Drayk Bowen leads the Notre Dame Fighting Irish with 55 tackles, Boubacar Traore has 6.5 sacks and Leonard Moore has 3 interceptions.

Pittsburgh Panthers Betting Preview


The Pittsburgh Panthers beat NC State and Stanford, and they play Georgia Tech next. Pittsburgh has won 5 straight games. Mason Heintschel is completing 64.1 percent of his passes for 1,547 yards, 12 touchdowns, and 5 interceptions. Raphael Williams Jr. and Kenny Johnson have combined for 1,098 receiving yards and 10 touchdowns, while Cataurus Hicks has 19 receptions.

The Pittsburgh Panthers ground game is averaging 124.4 yards per contest, and Ja’Kyrian Turner leads the way with 399 yards and 6 touchdowns. Defensively, Pittsburgh is allowing 21.8 points and 318.3 yards per game. Braylan Lovelace leads the Pittsburgh Panthers with 55 tackles, Jimmy Scott has 4 sacks and Kyle Louis has 2 interceptions.

Why the Pittsburgh Panthers will win

Why the Notre Dame Fighting Irish will win

Total Points Facts

Pittsburgh Panthers Player Prop Facts

Notre Dame Fighting Irish Player Prop Facts

Matchup/League Facts

Notre Dame vs Pittsburgh Prediction


Notre Dame is the more talented team and should be favored, but this is too much respect. Pittsburgh has one of the best offenses in the country that’s sixth in scoring, and the defense stops the run and is 23rd in total defense overall. Pitt doesn’t get the national love that Notre Dame gets, but this is a good team. Also, Pitt has covered its last 3 games as a double-digit underdog, and that includes an outright win this year over Florida State. Pitt is 7-2 ATS on the season. I wouldn’t be shocked if Notre Dame loses this game outright. Give me the points.

Randy Chambers's Pick: Pittsburgh +12.5

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