Nevada vs Wyoming Prediction 11/22/2025 Today’s College Football Picks

Chris Ruffolo

1 day ago

Oct 25, 2025; Laramie, Wyoming, USA; Wyoming Cowboys quarterback Kaden Anderson (12) celebrates a turnover on downs by the Colorado State Rams during the fourth quarter at Jonah Field at War Memorial Stadium. Mandatory Credit: Ron Chenoy-Imagn Images

MATCHUP	Nevada Wolf Pack	Wyoming Cowboys
Team Records	2-8	4-6
Spread	+6.5 -112	-6.5 -108
Moneyline	+200	-245
Total	Over 40.5 (-105)	Under 40.5 (-115)
Where	War Memorial Stadium, Laramie, WY
When	Saturday, November 22, 2025
Time	02:00 PM EST
TV	MWN

The Nevada Wolf Pack and the Wyoming Cowboys meet in week 13 college football action from War Memorial Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Nevada Wolf Pack vs. Wyoming Cowboys prediction.

Nevada Wolf Pack Recap

The Nevada Wolf Pack come into this game looking to build on their 55-10 blowout win over San Jose State last time out to sit at 2-8 this season. After this game, Nevada will head home for a game against UNLV.

Wolf Pack Snap Eight-Game Slide

Carter Jones has thrown for 856 yards, 5 touchdowns and 8 interceptions on 63.6% passing while Chubba Purdy has thrown for 577 yards, 3 touchdowns and 8 interceptions on 51.8% passing. Caleb Ramseur has rushed for a team-high 500 yards with 3 TDs while Purdy has 388 rushing yards and Herschel Turner has 318 rushing yards as well this season. Jett Carpenter leads Nevada’s receiving group with 28 grabs for 306 yards while Dakota Thomas and Marcus Bellon each have 200+ receiving yards as well this season. On defense, Dylan Labarbera has a team-high 76 total tackles and 6.5 sacks while Murvin Kenion III has 3 interceptions to lead Nevada’s defense. Jonathan Maldonado’s also added 5 sacks as well for the Wolf Pack defense. As a unit, Nevada’s defense has combined for 19 sacks and 9 interceptions so far this season.

Wyoming Cowboys Recap

The Wyoming Cowboys come into this game looking to bounce back from a 24-3 loss at the hands of Fresno State last time out to sit at 4-6 this season. After this game, Wyoming will head on the road for a game against Hawaii to close out the regular season.

Cowboys Drop Back-To-Back Games

Kaden Anderson has thrown for 1,791 yards, 11 touchdowns and 10 interceptions on 56.2% passing while Samuel Harris has 552 rushing yards and a touchdown and Sam Scott has 352 rushing yards and 2 touchdowns. Terron Kellman also has 331 rushing yards and 4 TDs this season. Chris Durr Jr. has a team-high 39 receptions for 435 receiving yards and 4 touchdowns as well this season. On defense, Brayden Johnson has a team-high 62 total tackles while Ben Florentine has a team-high 5 sacks as well this season. As a unit, Wyoming has combined for 17 sacks and 9 interceptions so far this season.

Nevada Wolf Pack @ Wyoming Cowboys Betting Trends: Week 13

Why the Wyoming Cowboys will win

Nevada has lost each of its last 10 road games.
The home team has won each of Wyoming’s last five games.
Wyoming has covered the spread in seven of its last eight home games in November.
Nevada has failed to cover the spread in four of its last five November games against non-AP-ranked teams.
Nevada has lost the first half in seven of its last eight games against conference opponents.

Why the Nevada Wolf Pack will win

Wyoming has lost four of its last five games in November.
Wyoming has failed to cover the spread in three of its last four November games against non-AP-ranked teams.

Total Points Facts

Each of Nevada’s last six November games as an underdog against non-AP-ranked teams have gone OVER the total points line.
Seven of Wyoming’s last eight games against conference opponents have gone UNDER the total points line.

Wyoming Cowboys Player Prop Facts

Heading into Week 13, Samuel Harris is one of only 17 players in the FBS to record 500 rushing yards with less than 100 attempts this season.

Nevada Wolf Pack Player Prop Facts

Heading into Week 13, Caleb Ramseur is one of only 11 players in the FBS to record 3+ rushing and 3+ receiving TDs this season.

Matchup/League Facts

Wyoming ranks 133rd among FBS teams for Q2 points per game this season (3.7).
Wyoming ranks 4th among FBS teams for red zone percentage against this season (69.0).
Nevada ranks 131st among FBS teams for red zone percentage this season (68.8).
Nevada ranks 130th among FBS teams for Q1 points per game this season (2.6).

Nevada Wolf Pack vs. Wyoming Cowboys Prediction

I’m on Wyoming here. I just think this is a Cowboys spot as Wyoming needs to win out for a bowl game and Nevada had their performance of the year last week against San Jose State and really have nothing but next week’s rivalry game with UNLV to have their attention on with no bowl game on the horizon. Wyoming has a solid home field advantage and we’ve seen better teams than Wyoming go into Laramie and fall down. I’ll stick with Wyoming in this one.