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Missouri vs Vanderbilt Prediction 10/25/2025 Today’s College Football Picks

Oct 18, 2025; Nashville, Tennessee, USA; Vanderbilt Commodores quarterback Diego Pavia (2) celebrates the win against the Louisiana State Tigers during the second half at FirstBank Stadium. Mandatory Credit: Steve Roberts-Imagn Images

Oct 18, 2025; Nashville, Tennessee, USA; Vanderbilt Commodores quarterback Diego Pavia (2) celebrates the win against the Louisiana State Tigers during the second half at FirstBank Stadium. Mandatory Credit: Steve Roberts-Imagn Images

MATCHUP Missouri Tigers Vanderbilt Commodores
Team Records 6-2 7-1
Where FirstBank Stadium, Nashville, TN
When Saturday, October 25, 2025
Time 03:30 PM EDT
TV ESPN

The Missouri Tigers and Vanderbilt Commodores meet Saturday in college football action at FirstBank Stadium. Here’s a Missouri vs Vanderbilt Prediction. This article will include a Missouri vs Vanderbilt Pick.

Missouri Tigers Betting Preview

The Missouri Tigers beat Auburn, lost to Alabama, and they play Texas A&M next. The Missouri Tigers have won 9 of their last 10 games. Beau Pribula is completing 70 percent of his passes for 1,617 yards, 11 touchdowns, and 7 interceptions. Marquis Johnson and Kevin Coleman Jr. have combined for 771 receiving yards and 3 touchdowns, while Brett Norfleet has 25 receptions.

The Missouri Tigers ground game is averaging 244.9 yards per contest, and Ahmad Hardy leads the way with 840 yards and 11 touchdowns. Defensively, Missouri is allowing 16.7 points and 243 yards per game. Josiah Trotter leads the Missouri Tigers with 44 tackles, Damon Wilson II has 5.5 sacks and Dante McClellan has 1 interception.

Vanderbilt Commodores Betting Preview

The Vanderbilt Commodores beat LSU, lost to Alabama, and they play Texas next. The Vanderbilt Commodores have 7 of their last 8 games. Diego Pavia is completing 70.5 percent of his passes for 1,569 yards, 15 touchdowns, and 4 interceptions. Eli Stowers and Junior Sherrill have combined for 659 receiving yards and 7 touchdowns, while Tre Richardson has 20 receptions.

The Vanderbilt Commodores ground game is averaging 213 yards per contest, and Diego Pavia leads the way with 438 yards and 4 touchdowns. Defensively, Vanderbilt is allowing 20 points and 315 yards per game. CJ Heard leads the Vanderbilt Commodores with 35 tackles, Miles Capers has 4.5 sacks and Martel Hight has 1 interception.

Why the Vanderbilt Commodores will win

Why the Missouri Tigers will win

Total Points Facts

Vanderbilt Commodores Player Prop Facts

Missouri Tigers Player Prop Facts

Matchup/League Facts

Missouri vs Vanderbilt Prediction

Vanderbilt is legit with a star at quarterback and an udneratted defense, so I’m not surprised they’re favored at home. However, the value is with Missouri and the free points. Missouri is a top-10 rushing team and one of the best defenses in the country. Missouri is built to win on the road and is sure to have a game plan to slow down Pavia and all of his hype. These are two solid teams overall, so whichever team was getting points would have been the side I was on. Either team winning wouldn’t be surprising. Just don’t sleep on Missouri, is all I’m saying. Give me the points.

Randy Chambers's Pick: Missouri +2.5

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