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Missouri vs Oklahoma Prediction 11/22/2025 Today’s College Football Picks

Oklahoma running back Tory Blaylock (6) is warmped by Tennessee linebacker Edwin Spillman (13), Tennessee linebacker Arion Carter (7) and Tennessee defensive lineman Daevin Hobbs (5) during a NCAA football game between the Tennessee Volunteers and Oklahoma Sooners at Neyland Stadium in Knoxville, Tenn., on November 1, 2025.

Oklahoma running back Tory Blaylock (6) is warmped by Tennessee linebacker Edwin Spillman (13), Tennessee linebacker Arion Carter (7) and Tennessee defensive lineman Daevin Hobbs (5) during a NCAA football game between the Tennessee Volunteers and Oklahoma Sooners at Neyland Stadium in Knoxville, Tenn., on November 1, 2025.

MATCHUP Missouri Tigers Oklahoma Sooners
Team Records 7-3 8-2
Spread +7.5 -110 -7.5 -110
Moneyline +250 -310
Total Over 41.5 (-112) Under 41.5 (-108)
Where Memorial Stadium (Norman, OK), Norman, OK
When Saturday, November 22, 2025
Time 12:00 PM EST
TV ABC
The Missouri Tigers and Oklahoma Sooners meet Saturday in college football action at Memorial Stadium. Here’s a Missouri vs Oklahoma Prediction. This article will include a Missouri vs Oklahoma Pick.

Missouri Tigers Betting Preview


The Missouri Tigers lost to Texas A&M, beat Mississippi State, and they play Arkansas next. The Missouri Tigers have split their last 6 games. Beau Pribula is completing 69.6 percent of his passes for 1,685 yards, 11 touchdowns, and 7 interceptions. Marquis Johnson and Kevin Coleman Jr. have combined for 940 receiving yards and 3 touchdowns, while Donovan Olugbode has 22 receptions.

The Missouri Tigers ground game is averaging 241.7 yards per contest, and Ahmad Hardy leads the way with 1,346 yards and 15 touchdowns. Defensively, Missouri is allowing 19.9 points and 277.5 yards per game. Josiah Trotter leads the Missouri Tigers with 61 tackles, Damon Wilson II has 7 sacks and Toriano Pride Jr. has 2 interceptions.

Oklahoma Sooners Betting Preview


The Oklahoma Sooners beat Tennessee and Alabama, and play LSU next. Oklahoma has won 10 of its last 5 games. John Mateer is completing 63.9 percent of his passes for 2,087 yards, 8 touchdowns, and 7 interceptions. Isaiah Sategna III and Deion Burks have combined for 1,172 receiving yards and 7 touchdowns, while Jaren Kanak has 32 receptions.

The Oklahoma Sooners ground game is averaging 130.7 yards per contest, and Tory Blaylock leads the way with 402 yards and 4 touchdowns. Defensively, Oklahoma is allowing 14.8 points and 278.4 yards per game. Kip Lewis leads the Oklahoma Sooners with 60 tackles, R Mason Thomas has 6.5 sacks and Taylor Wein has 1 interception.

Why the Oklahoma Sooners will win

Why the Missouri Tigers will win

Total Points Facts

Oklahoma Sooners Player Prop Facts

Missouri Tigers Player Prop Facts

Matchup/League Facts

Missouri vs Oklahoma Prediction


I originally was leaning toward Missouri and the points, especially with us getting a hook on top of a key number. However, Missouri has come up small in every big game this season and is 0-3 SU and 0-2-1 ATS as an underdog this season. Missouri has lost those games by an average of 10.3 points. Oklahoma is coming off monster road wins over Tennessee and Alabama, which are signs this team has figured things out and ready to make a playoff push. Oklahoma is 11-5 ATS in its last 16 games as a home favorite. Oklahoma is 7-4 ATS in its last 11 games when favorites of 5 or more points. I’ll lay the number with Oklahoma at home.

Randy Chambers's Pick: Oklahoma -7.5

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