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Mississippi State vs South Carolina Prediction 9/19/2026 Today’s College Football Picks

Sep 12, 2026; Columbia, South Carolina, USA;  South Carolina Gamecocks running back Matt Fuller (28) rushes for a 55-yard touchdown against the Towson Tigers in the second quarter at Williams-Brice Stadium.  Mandatory Credit: Jeff Blake-Imagn Images

Sep 12, 2026; Columbia, South Carolina, USA; South Carolina Gamecocks running back Matt Fuller (28) rushes for a 55-yard touchdown against the Towson Tigers in the second quarter at Williams-Brice Stadium. Mandatory Credit: Jeff Blake-Imagn Images

MATCHUP Mississippi State Bulldogs South Carolina Gamecocks
Team Records 2-0 2-0
Spread +4 -112 -4 -108
Moneyline +145 -175
Total Over 58.5 (-112) Under 58.5 (-108)
Where Williams-Brice Stadium, Columbia, SC
When Saturday, September 19, 2026
Time 04:15 PM EDT
TV SEC Network
The Mississippi State Bulldogs and South Carolina Gamecocks meet Saturday in week 3 college football action at Williams-Brice Stadium. Here’s a Mississippi State vs. South Carolina Prediction. This article will include a Mississippi State vs. South Carolina Pick.

Mississippi State Bulldogs Betting Preview 


The Mississippi State Bulldogs beat UL Monroe and Minnesota, and they play Missouri next. Mississippi State has lost 8 of its last 11 games. Kamario Taylor is completing 67.9 percent of his passes for 581 yards, 7 touchdowns, and 0 interceptions. Anthony Evans III and Marquis Johnson have combined for 346 receiving yards and 3 touchdowns, while Zion Ragins has 6 receptions. 

The Mississippi State Bulldogs’ ground game is averaging 298.5 yards per contest, and Fluff Bothwell leads the way with 165 yards and 2 touchdowns. On defense, Mississippi State allows 13 points and 285 yards per game. Jalen Smith leads the Mississippi State Bulldogs with 12 tackles, Trevion Williams has 1 sack, and Kelley Jones has 2 pass deflections.

South Carolina Gamecocks Betting Preview 


The South Carolina Gamecocks beat Kent State and Towson, and will play Alabama next. The South Carolina Gamecocks look to start 3-0 for the first time since the 2012 season. LaNorris Sellers is completing 63 percent of his passes for 366 yards, 3 touchdowns, and 1 interception. Nyck Harbor and Donovan Murph have combined for 197 receiving yards and 2 touchdowns, while DJ Black has 3 receptions. 

The South Carolina Gamecocks’ ground game averages 341.5 yards per contest, and Matt Fuller leads with 199 yards and 2 touchdowns. On defense, South Carolina allows 4.5 points and 191 yards per game. Andrew Harris leads the South Carolina Gamecocks with 22 tackles, J’Zavien Currence has 1 sack, and Quay’sheed Scott has 2 pass deflections.
Why the South Carolina Gamecocks will win

Why the Mississippi State Bulldogs will win

Total Points Facts

South Carolina Gamecocks Player Prop Facts

Mississippi State Bulldogs Player Prop Facts

Matchup/League Facts

Mississippi State vs South Carolina Prediction


Mississippi State has had the tougher schedule up to this point, but it’s tough to play back-to-back road games against respectable opponents. South Carolina has also been imrpvoed defensively up to this point and has a quarterback who could be in for a turnaround season. Remember, it wasn’t that long ago that Sellers was in Heisman talks and was a first-round NFL draft pick. This is a big season for the Gamecocks. Statement game. The line isn’t anything crazy. I’ll lay the points with South Carolina at home, as I like the upside of this team.

Randy Chambers's Pick: South Carolina -4

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