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Mississippi State vs Missouri Prediction 11/15/2025 Today’s College Football Picks

Oct 25, 2025; Nashville, Tennessee, USA;  Missouri Tigers running back Ahmad Hardy (29) runs with the ball against the Vanderbilt Commodores during the first half at FirstBank Stadium. Mandatory Credit: Steve Roberts-Imagn Images

Oct 25, 2025; Nashville, Tennessee, USA; Missouri Tigers running back Ahmad Hardy (29) runs with the ball against the Vanderbilt Commodores during the first half at FirstBank Stadium. Mandatory Credit: Steve Roberts-Imagn Images

MATCHUP Mississippi State Bulldogs Missouri Tigers
Team Records 5-5 6-3
Spread +7 -112 -7 -108
Moneyline +220 -270
Total Over 51.5 (-105) Under 51.5 (-115)
Where Memorial Stadium, Columbia, MO
When Saturday, November 15, 2025
Time 07:45 PM EST
TV SEC Network
The Mississippi State Bulldogs and Missouri Tigers meet Saturday in college football action at Memorial Stadium. Here’s a Mississippi State vs Missouri Prediction. This article will include a Mississippi State vs Missouri Pick.

Mississippi State Bulldogs Betting Preview


The Mississippi State Bulldogs lost to Georgia, beat Arkansas, and they play Ole Miss next. Mississippi State has lost 5 of its last 6 games. Blake Shapen is completing 65.2 percent of his passes for 2,234 yards, 15 touchdowns, and 6 interceptions. Brenen Thompson and Anthony Evans III have combined for 1,488 receiving yards and 10 touchdowns, while Seydou Traore has 27 receptions.

The Mississippi State Bulldogs ground game is averaging 156.8 yards per contest, and Fluff Bothwell leads the way with 534 yards and 6 touchdowns. Defensively, Mississippi State is allowing 26.3 points and 388.7 yards per game. Jahron Manning leads the Mississippi State Bulldogs with 70 tackles, Will Whitson has 2 sacks and Brylan Lanier has 3 interceptions.

Missouri Tigers Betting Preview


The Missouri Tigers lost to Vanderbilt and Texas A&M, and they play Oklahoma next. The Missouri Tigers have lost 3 of their last 4 games. Beau Pribula is completing 69.6 percent of his passes for 1,685 yards, 11 touchdowns, and 7 interceptions. Marquis Johnson and Kevin Coleman Jr. have combined for 899 receiving yards and 3 touchdowns, while Donovan Olugbode has 20 receptions.

The Missouri Tigers ground game is averaging 232.3 yards per contest, and Ahmad Hardy leads the way with 1,046 yards and 12 touchdowns. Defensively, Missouri is allowing 19.1 points and 270 yards per game. Josiah Trotter leads the Missouri Tigers with 59 tackles, Damon Wilson II has 6.5 sacks and Dante McClellan has 1 interception.

Why the Missouri Tigers will win

Why the Mississippi State Bulldogs will win

Total Points Facts

Missouri Tigers Player Prop Facts

Mississippi State Bulldogs Player Prop Facts

Matchup/League Facts

Mississippi State vs Missouri Prediction


Missouri is the better, more balanced team, but it’s been shaky over the last month, and that includes scoring 24 or fewer points in each of its last 3 games. Missouri has scored a combined 27 points in its last 2 games. Mississippi State doesn’t play much defense, but it has the offense to give Missouri a scare. Mississippi State is also one of the best cover teams in the country with an 8-2 ATS record. Mississippi State also needs one more win to become bowl eligible, so this is still a big game for the Bulldogs. I’ll take a free touchdown with a team that’s covering numbers left and right.

Randy Chambers's Pick: Mississippi State +7

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