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Michigan vs USC Prediction 10/11/2025 Today’s College Football Picks

Sep 27, 2025; Champaign, Illinois, USA;  Southern California Trojans running back Waymond Jordan (2) runs through the Illinois Fighting Illini defensive line during the second half at Memorial Stadium. Mandatory Credit: Ron Johnson-Imagn Images

Sep 27, 2025; Champaign, Illinois, USA; Southern California Trojans running back Waymond Jordan (2) runs through the Illinois Fighting Illini defensive line during the second half at Memorial Stadium. Mandatory Credit: Ron Johnson-Imagn Images

MATCHUP Michigan Wolverines USC Trojans
Team Records 4-2 5-1
Where Los Angeles Memorial Coliseum, Los Angeles, CA
When Saturday, October 11, 2025
Time 07:30 PM EDT
TV NBC

The Michigan Wolverines and USC Trojans meet Saturday in college football action at Los Angeles Memorial Coliseum. Here’s a Michigan vs USC Prediction. This article will include a Michigan vs USC Pick.

Michigan Wolverines Betting Preview

The Michigan Wolverines beat Wisconsin and Nebraska, and they play Washington next. Michigan has won 7 of its last 8 games. Bryce Underwood is completing 59.2 percent of his passes for 1,003 yards, 3 touchdowns, and 1 interception. Donaven McCulley and Semaj Morgan have combined for 496 receiving yards and 2 touchdowns, while Marlin Klein has 11 receptions.

The Michigan Wolverines ground game is averaging 237.8 yards per contest, and Justice Haynes leads the way with 654 yards and 8 touchdowns. Defensively, Michigan is allowing 16.2 points and 283.8 yards per game. Ernest Hausmann leads the Michigan Wolverines with 31 tackles, Jaishawn Barham has 3 sacks and Cole Sullivan has 2 interceptions.

USC Trojans Betting Preview

The USC Trojans beat Michigan State, lost to Illinois and play Notre Dame next. The USC Trojans have won 7 of their last 9 games. Jayden Maiava is completing 70.5 percent of his passes for 1,587 yards, 11 touchdowns and 1 interception. Makai Lemon and Jacobi Lane have combined for 867 receiving yards and 6 touchdowns, while Lake McRee has 12 receptions.

The USC Trojans ground game is averaging 227 yards per contest, and Waymond Jordan leads the way with 537 yards and 5 touchdowns. Defensively, USC is allowing 23 points and 359.4 yards per game. Eric Gentry leads the USC Trojans with 35 tackles, Braylan Shelby has 3.5 sacks and Bishop Fitzgerald has 3 interceptions.

Why the USC Trojans will win

Why the Michigan Wolverines will win

Total Points Facts

USC Trojans Player Prop Facts

Michigan Wolverines Player Prop Facts

Matchup/League Facts

Michigan vs USC Prediction

USC is getting a lot of love because it’s at home, and it doesn’t hurt to be led by one of the best offenses in the country. However, we’re getting points with the better team overall, and there’s usually value in this business when you can find spots like this. Michigan is the more proven team up to this point with notable wins, and its defense is far more trustworthy. USC can’t stop the pass at all, so a young potential star QB in Underwood will have his chances to make plays through the air. Should be a fun one, but I want the points with the Wolverines.

Randy Chambers's Pick: Michigan Wolverines +2.5

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