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Michigan State vs Indiana Prediction 10/18/2025 Today’s College Football Picks

Oct 11, 2025; Eugene, Oregon, USA; Indiana Hoosiers running back Roman Hemby (1) runs the ball against the Oregon Ducks during the fourth quarter at Autzen Stadium. Mandatory Credit: Troy Wayrynen-Imagn Images

Oct 11, 2025; Eugene, Oregon, USA; Indiana Hoosiers running back Roman Hemby (1) runs the ball against the Oregon Ducks during the fourth quarter at Autzen Stadium. Mandatory Credit: Troy Wayrynen-Imagn Images

MATCHUP Michigan State Spartans Indiana Hoosiers
Team Records 3-4 7-0
Where Memorial Stadium (Bloomington, IN), Bloomington, IN
When Saturday, October 18, 2025
Time 03:30 PM EDT
TV Peacock

The Michigan State Spartans and Indiana Hoosiers meet Saturday in college football action at Memorial Stadium. Here’s a Michigan State vs Indiana Prediction. This article will include a Michigan State vs Indiana Pick.

Michigan State Spartans Betting Preview

The Michigan State Spartans lost to USC and Nebraska and plays Michigan next. The Michigan State Spartans have lost 3 straight games. Aidan Chiles is completing 61.3 percent of his passes for 1,019 yards, 9 touchdowns and 3 interceptions. Nick Marsh and Omari Kelly have combined for 687 receiving yards and 5 touchdowns, while Chrishon McCray has 9 receptions.

The Michigan State Spartans ground game is averaging 131.2 yards per contest, and Makhi Frazier leads the way with 383 yards and 2 touchdowns. Defensively, Michigan State is allowing 31.8 points and 369.2 yards per game. Jordan Hall leads the Michigan State Spartans with 45 tackles, Malik Spencer has 2 sacks and Armorion Smith has 1 interception.

Indiana Hoosiers Betting Preview

The Indiana Hoosiers beat Iowa and Oregon, and they play UCLA next. Indiana has won 6 straight games. Fernando Mendoza is completing 71.3 percent of his passes for 1,423 yards, 17 touchdowns, and 2 interceptions. Elijah Sarratt and Omar Cooper Jr. have combined for 999 receiving yards and 13 touchdowns, while E.J. Williams Jr. has 14 receptions.

The Indiana Hoosiers ground game is averaging 241.7 yards per contest, and Roman Hemby leads the way with 421 yards and 2 touchdowns. Defensively, Indiana is allowing 11.3 points and 229 yards per game. Louis Moore leads the Indiana Hoosiers with 38 tackles, Isaiah Jones has 4.5 sacks and Amare Ferrell has 3 interceptions.

Why the Indiana Hoosiers will win

Why the Michigan State Spartans will win

Total Points Facts

Indiana Hoosiers Player Prop Facts

Michigan State Spartans Player Prop Facts

Matchup/League Facts

Michigan State vs Indiana Prediction

Michigan State is a mess defensively and doesn’t have the playmakers on offense to scare anybody. On paper, Indiana should run away with this contest. However, this is a letdown spot for Indiana after just beating Oregon on the road. Michigan State has also covered its last 3 games as a double-digit underdog. While there’s a massive gap in talent, this just feels like a lot of points, and we’ve seen Sparty find ways to hang around this season. I’ll grab my free touchdowns.

Randy Chambers's Pick: Michigan State +27

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