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LSU vs Vanderbilt Prediction 10/18/2025 Today’s College Football Picks

MATCHUP LSU Tigers Vanderbilt Commodores
Team Records 5-2 6-1
Where FirstBank Stadium, Nashville, TN
When Saturday, October 18, 2025
Time 12:00 PM EDT
TV ABC

The LSU Tigers and the Vanderbilt Commodores meet in week 8 college football action from FirstBank Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an LSU Tigers vs. Vanderbilt Commodores prediction.

LSU Tigers Recap

The LSU Tigers come into this game looking to add on to their 20-10 win over South Carolina last time out to sit at 5-1 this season. After this game, LSU will head home for a game against Texas A&M. 

Tigers Looking To Secure Bowl Eligibility

Garrett Nussmeier has thrown for 1,413 yards, 9 touchdowns and 5 interceptions on 66.2% passing while Caden Durham has rushed for 283 yards and 2 touchdowns so far this season. Aaron Anderson has a team-high 305 receiving yards with 23 catches while Barion Brown has a team-high 27 catches for 261 yards and a score. Four more Tigers have 100+ receiving yards as well this season. On defense, West Weeks has a team-high 40 total tackles while A.J. Haulcy has 38 total tackles with a team-high 25 solo tackles. As a unit, LSU’s defense has combined for 16 sacks and 8 interceptions so far this season. 

Vanderbilt Commodores Recap

The Vanderbilt Commodores come into this game looking to bounce back from a 30-14 loss to Alabama prior to last week’s bye week to fall to 5-1 this season. After this game, Vanderbilt will take on Missouri in a matchup at home.

Commodores Looking To Shake Off First Loss

Diego Pavia has thrown for 1,409 yards, 14 touchdowns and 4 interceptions on 71.4% passing while also leading Vanderbilt in rushing with 352 rushing yards and 2 touchdowns. Sedrick Alexander has 319 rushing yards and a team-high 5 touchdowns while Makhilyn Young has 211 rushing yards and 4 TDs. Eli Stowers leads Vanderbilt’s receiving group with 25 grabs for 323 yards and 2 touchdowns while Junior Sherrill has 23 catches for 274 yards and a team-high 5 touchdowns. Tre Richardson has 20 catches for 242 yards and Richie Hoskins has 156 receiving yards as well this season. On defense, CJ Heard has a team-high 31 total tackles while Miles Capers has a team-high 4.5 sacks as well this season. As a unit, Vanderbilt has combined for 18 sacks and 4 interceptions so far this season. 

LSU Tigers @ Vanderbilt Commodores Betting Trends: Week 8

Why the Vanderbilt Commodores will win

Why the LSU Tigers will win

Total Points Facts

Vanderbilt Commodores Player Prop Facts

LSU Tigers Player Prop Facts

Matchup/League Facts

LSU Tigers vs. Vanderbilt Commodores Prediction

I’m on Vanderbilt here. I just think that Vanderbilt is the better team in this matchup and while it’s not often that they’ll lay points in this matchup, I think they are for a reason here. I just don’t believe that this LSU team is the same LSU team that came into the season as hyped as they were and I honestly don’t think that Garrett Nussmeier is healthy which is a big problem for this LSU offense. I’ll roll with Vandy to get the win at home in this one.

Chris Ruffolo's Pick: Vanderbilt -3

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