LSU vs Vanderbilt Prediction 10/18/2025 Today’s College Football Picks

The LSU Tigers and the Vanderbilt Commodores meet in week 8 college football action from FirstBank Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an LSU Tigers vs. Vanderbilt Commodores prediction.

LSU Tigers Recap

The LSU Tigers come into this game looking to add on to their 20-10 win over South Carolina last time out to sit at 5-1 this season. After this game, LSU will head home for a game against Texas A&M. 

Tigers Looking To Secure Bowl Eligibility

Garrett Nussmeier has thrown for 1,413 yards, 9 touchdowns and 5 interceptions on 66.2% passing while Caden Durham has rushed for 283 yards and 2 touchdowns so far this season. Aaron Anderson has a team-high 305 receiving yards with 23 catches while Barion Brown has a team-high 27 catches for 261 yards and a score. Four more Tigers have 100+ receiving yards as well this season. On defense, West Weeks has a team-high 40 total tackles while A.J. Haulcy has 38 total tackles with a team-high 25 solo tackles. As a unit, LSU’s defense has combined for 16 sacks and 8 interceptions so far this season. 

Vanderbilt Commodores Recap

The Vanderbilt Commodores come into this game looking to bounce back from a 30-14 loss to Alabama prior to last week’s bye week to fall to 5-1 this season. After this game, Vanderbilt will take on Missouri in a matchup at home.

Commodores Looking To Shake Off First Loss

Diego Pavia has thrown for 1,409 yards, 14 touchdowns and 4 interceptions on 71.4% passing while also leading Vanderbilt in rushing with 352 rushing yards and 2 touchdowns. Sedrick Alexander has 319 rushing yards and a team-high 5 touchdowns while Makhilyn Young has 211 rushing yards and 4 TDs. Eli Stowers leads Vanderbilt’s receiving group with 25 grabs for 323 yards and 2 touchdowns while Junior Sherrill has 23 catches for 274 yards and a team-high 5 touchdowns. Tre Richardson has 20 catches for 242 yards and Richie Hoskins has 156 receiving yards as well this season. On defense, CJ Heard has a team-high 31 total tackles while Miles Capers has a team-high 4.5 sacks as well this season. As a unit, Vanderbilt has combined for 18 sacks and 4 interceptions so far this season. 

LSU Tigers @ Vanderbilt Commodores Betting Trends: Week 8

Why the Vanderbilt Commodores will win

• Vanderbilt has won each of its last nine games as a home favorite.
• LSU has lost four of its last five October road games against AP-ranked teams.
• LSU has failed to cover the spread in six of its last seven October road games against AP-ranked teams.
• The favorite has covered the spread in four of Vanderbilt’s last five games at FirstBank Stadium.

Why the LSU Tigers will win

• Vanderbilt has lost 32 of its last 34 games against top-15 AP-ranked teams.
• LSU has won eight of its last nine games.
• LSU has covered the spread in eight of its last nine games in October.
• Vanderbilt has failed to cover the spread in each of its last five October games as a favorite.
• LSU has won the first quarter in three of its last four road games against conference opponents.
• Vanderbilt has lost the first half in eight of its last nine home games against conference opponents.

Total Points Facts

• Six of LSU’s last seven games against conference opponents have gone UNDER the total points line.
• Ten of Vanderbilt’s last 12 games as a favorite have gone OVER the total points line.

Vanderbilt Commodores Player Prop Facts

• Heading into Week 8, Sedrick Alexander leads the Southeastern Conference for touchdowns (9) this season.

LSU Tigers Player Prop Facts

• Heading into Week 8, Grant Chadwick ranks 7th amongst qualified players for gross average yards per punt (48.0) this season.

Matchup/League Facts

• Vanderbilt ranks 2nd among FBS teams for 3rd down conversion percentage this season (57.9).
• Vanderbilt ranks T6th among FBS teams for average point differential in third quarters this season (+7.7).
• LSU has recorded the equal-most home wins by a margin of 10+ points of any FBS team this season (4).
• LSU ranks T3rd among FBS teams for 4th down conversion percentage this season (83.3).

LSU Tigers vs. Vanderbilt Commodores Prediction

I’m on Vanderbilt here. I just think that Vanderbilt is the better team in this matchup and while it’s not often that they’ll lay points in this matchup, I think they are for a reason here. I just don’t believe that this LSU team is the same LSU team that came into the season as hyped as they were and I honestly don’t think that Garrett Nussmeier is healthy which is a big problem for this LSU offense. I’ll roll with Vandy to get the win at home in this one.