LSU vs Ole Miss Prediction 9/19/2026 Today’s College Football Picks

In this article we will formulate a LSU vs Ole Miss prediction for this College Football game on Saturday, September 19th at Vaught-Hemingway Stadium in Oxford, Mississippi. Let’s take a look at the prediction for this Week 3 matchup. 

LSU Tigers Betting Preview

The LSU Tigers are 2-0 this season after they defeated Louisiana Tech by a score of 45-14 last week. LSU led 10-7 at halftime after a terrible first half, but they scored 35 points in the second half to pull away with the win. The Tigers out gained La Tech by a total of 528-140, went 8-17 on third downs, and lost the turnover battle by a total of 4-3 in the game. Sam Leavitt threw for 344 yards, one touchdown, and three interceptions, while Trey’Dez Green caught six passes for 104 yards and one score. Dilin Jones rushed 18 times for 66 yards in the game. 

Prior to that win, LSU defeated Clemson by a score of 51-10 in week one. The Tigers have scored 48.0 points per game with 358.0 passing yards and 228.0 rushing yards per game, while they have allowed 12.0 points against per game this season. Sam Leavitt has thrown for 574 yards, two touchdowns, and four interceptions, while Trey’Dez Green has 10 receptions for 162 yards and one touchdown. Dilin Jones has rushed 41 times for 179 yards and two scores this season. 

Ole Miss Rebels Betting Preview

The Ole Miss Rebels are 2-0 this year after they defeated Charlotte by a score of 41-9 in week two. Ole Miss led 27-0 at halftime, but they only scored 14 points in the second half in the easy win. The Rebels out gained Charlotte by a total of 420-322, went 1-4 on third downs, and tied the turnover battle by a total of 1-1 in the game. Trinidad Chambliss threw for 225 yards and two touchdowns, while Deuce Alexander caught eight passes for 76 yards. Kewan Lacy rushed 13 times for 87 yards and two scores in the win. 

Prior to that game, Ole Miss defeated Louisville by a score of 41-38 in week one. The Rebels have scored 41.0 points per game with 314.5 passing yards and 139.5 rushing yards per game, while they have allowed 23.5 points against per game this season. Trinidad Chambliss has thrown for 561 yards, five touchdowns, and one interception, while Deuce Alexander has 13 receptions for 235 yards and two scores this year. 

Why the Ole Miss Rebels will win

• Ole Miss has won each of its last 13 games at Vaught-Hemingway Stadium.
• LSU has lost each of its last three September games as a favorite against AP-ranked teams.
• The home team has covered the spread in 12 of the last 13 games between LSU and Ole Miss.
• LSU has failed to cover the spread in each of its last four games at Vaught-Hemingway Stadium.
• LSU has lost the first half in six of its last seven games against teams from Mississippi.

Why the LSU Tigers will win

• The favorite has won each of LSU’s last 14 games.
• Ole Miss has lost eight of its last nine September games as an underdog.
• The team ranked 7th in the AP Poll has covered the spread in four of its last five games.
• Ole Miss has failed to cover the spread in each of its last three games.
• Ole Miss has lost the first half in five of its last six games as a top-10 AP-ranked team against a top-10 AP-ranked team.

Total Points Facts

• Seven of Ole Miss’ last eight games at Vaught-Hemingway Stadium have gone UNDER the total points line.
• Each of LSU’s last four road games against top-15 AP-ranked teams have gone UNDER the total points line.

Ole Miss Rebels Player Prop Facts

• Trinidad Chambliss has recorded 20+ completions in eight consecutive games – longest streak in the FBS, heading into Week 3.

LSU Tigers Player Prop Facts

• Heading into Week 3, Dilin Jones ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

• Ole Miss ranks T5th among FBS teams for Q4 points per game this season (15.5).
• Ole Miss ranks T5th among FBS teams for H1 opponent points per game this season (3.0).
• LSU ranks T1st among FBS teams for 1st downs against this season (16).
• LSU ranks T1st among FBS teams for 4th down conversion percentage this season (100.0).

LSU vs Ole Miss Prediction 

Both of these teams come into this matchup with a 2-0 record to start the season and it will be Lane Kiffin’s first trip back to Ole Miss. This should be a fantastic game between two great teams, but the Lane Kiffin factor will make this one wild. Ole Miss needed a late push to escape Louisville in week one, but they have an elite offense. LSU looked dominant against Clemson in week one, but they really struggled in their win last week against La Tech. I don’t think we are going to see much defense in this one, so I like the over here.

David Racey's Pick: Over 58.5