Louisville vs Ole Miss Prediction 9/6/2026 Today’s College Football Picks

Nikos Lagouretos

1 hour ago

Ole Miss running back Kewan Lacy (5) jumps over a defender during a college football game between Ole Miss and LSU at Vaught-Hemingway Stadium in Oxford, Miss., on Saturday, Sept. 27, 2025. Ole Miss defeated LSU 24-19.

MATCHUP	Louisville Cardinals	Ole Miss Rebels
Team Records	0-0	0-0
Spread	+6.5 -102	-6.5 -118
Moneyline	+220	-270
Total	Over 55.5 (-105)	Under 55.5 (-115)
Where	Nissan Stadium, Nashville, TN
When	Sunday, September 6, 2026
Time	07:30 PM EDT
TV	ABC

In this article, we will formulate a Louisville vs Ole Miss Prediction for this College Football Week 1 matchup on Sunday, September 6th. Let’s take a look at the prediction for this College Football matchup.

Ole Miss Rebels Preview

Ole Miss finished last season with a 13-2 overall record, a 7-1 conference record, and placed 1st in the Southeastern. They had a 9-0 home record and a 3-1 road record. Offensively, the Rebels scored 36.9 points per game (ranking 10th in the nation). Defensively, Ole Miss allowed 21.1 points per game (ranking 37th in the nation). They averaged 489.7 total yards per game (176.3 rushing, 313.3 passing) and gave up 348.0 total yards per game (149.1 rushing, 198.9 passing).

Trinidad Chambliss led the Rebels with 294/444 completed passes and 3,937 total passing yards, throwing 22 touchdowns and 7 interceptions. Kewan Lacy led the team in rushing yards with 1,567, adding 24 touchdowns, while Harrison Wallace III had a team-high 61 caught passes for 934 receiving yards. Defensively, T.J. Dudley led the team with 98 total tackles (48 solo), while Princewill Umanmielen led Ole Miss in sacks with 9.0.

Louisville Cardinals Preview

Louisville finished last season with a 9-4 overall record, a 4-4 conference record, and placed 7th in the Atlantic Coast. They had a 5-3 home record and a 3-1 road record. Offensively, the Cardinals scored 29.9 points per game (ranking 46th in the nation). Defensively, Louisville allowed 21.2 points per game (ranking 38th in the nation). They averaged 384.5 total yards per game (163.9 rushing, 220.6 passing) and gave up 303.1 total yards per game (114.3 rushing, 188.8 passing).

Miller Moss led the Cardinals with 244/380 completed passes and 2,679 total passing yards, throwing 16 touchdowns and 7 interceptions. Isaac Brown led the team in rushing yards with 884, adding 8 touchdowns, while Caullin Lacy had a team-high 60 caught passes for 635 receiving yards. Defensively, TJ Quinn led the team with 95 total tackles (45 solo), while Clev Lubin led Louisville in sacks with 8.5.

Louisville Cardinals @ Ole Miss Rebels Betting Trends: Week 1

Why the Ole Miss Rebels will win

Ole Miss has won each of its last 13 games as a favorite.
Louisville has lost each of its last six games against AP-ranked teams at neutral venues.
The team ranked 9th in the AP Poll has covered the spread in seven of its last eight games.
Louisville has failed to cover the spread in each of its last five games as an AP-ranked team at neutral venues.
Ole Miss has won the first half in 28 of its last 30 September games as an AP-ranked team.
Ole Miss has won the first quarter in eight of its last nine games.

Why the Louisville Cardinals will win

Louisville has won three of its last four games as an underdog against top-10 AP-ranked teams.
Ole Miss has lost 10 of its last 13 games as a top-10 AP-ranked team against an AP-ranked team.
Louisville has covered the spread in four of its last five games as an underdog.
Ole Miss has failed to cover the spread in 10 of its last 13 games as a top-10 AP-ranked team against an AP-ranked team.
Louisville has won the first quarter in three of its last four games as an underdog against top-10 AP-ranked teams.
The team ranked 24th in the AP Poll has won the first half in five of its last six games.

Total Points Facts

Each of Ole Miss’ last six games as a favorite against AP-ranked teams have gone UNDER the total points line.
Ten of Louisville’s last 12 games against non-conference opponents have gone OVER the total points line.

Ole Miss Rebels Player Prop Facts

Trinidad Chambliss has recorded 275+ passing yards in six consecutive games – longest streak in the FBS.

Louisville Cardinals Player Prop Facts

Isaac Brown ranked 1st amongst qualified players for Yards Per Carry (8.8) last season.

Matchup/League Facts

Ole Miss recorded the equal-most home wins by a margin of 10 points or less of any FBS team last season (4).
Ole Miss ranked 1st among FBS teams for 1st downs last season (383).
Louisville ranked T11th among FBS teams for Q3 opponent points per game last season (3.0).
Louisville ranked 11th among FBS teams for 4th down conversion percentage against last season (38.5).

Louisville vs Ole Miss Prediction

In this Louisville vs Ole Miss Prediction, Ole Miss is coming as -6.5 home favorites. Ole Miss is coming off a dominating season where they lost only once in the conference and twice overall, while being very strong against the spread with a 9-6 ATS record. On the flip side, Louisville was just 4-9 ATS, but very strong at home and had similar defensive numbers as Ole Miss, but they had a much weaker offense, scoring 7 points less than Ole Miss, who had the 10th-most points scored in the entire country. Ole Miss is projected as #12 in the nation this season, while Louisville #18. I will be a hard-fought battle but I expect Ole Miss to win and cover the small number in front of their home crowd.