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Lafayette vs UConn Prediction 9/5/2026 Today’s College Football Picks

Oct 18, 2025; Chestnut Hill, Massachusetts, USA; UConn Huskies quarterback Joe Fagnano (2) looks to pass the ball during the first half against the Boston College Eagles at Alumni Stadium. Mandatory Credit: Bob DeChiara-Imagn Images

Oct 18, 2025; Chestnut Hill, Massachusetts, USA; UConn Huskies quarterback Joe Fagnano (2) looks to pass the ball during the first half against the Boston College Eagles at Alumni Stadium. Mandatory Credit: Bob DeChiara-Imagn Images

MATCHUP Lafayette Leopards UConn Huskies
Team Records 0-0 0-0
Spread +19.5 -108 -19.5 -112
Moneyline +800 -1350
Total Over 51.5 (-112) Under 51.5 (-108)
Where Pratt & Whitney Stadium, East Hartford, CT
When Saturday, September 5, 2026
Time 12:00 PM EDT
TV UConn+
In this article, we will formulate a Lafayette vs UConn Prediction for this College Football Week 1 matchup on Saturday, September 5th. Let’s take a look at the prediction for this College Football matchup.

UConn Huskies Preview


UConn finished the season with a 9-4 overall record and competed as an FBS Independent. They had a 6-1 home record and a 3-3 away record. Offensively, the Huskies scored 35.3 points per game last season (ranking 15th in the nation). Defensively, they allowed 27 points per game (ranking 81st in the nation). UConn averaged 445.2 total yards per game last season, with 160.8 average rushing yards and 284.4 average passing yards per game. They allowed 418.0 total yards per game, 199.5 of them rushing and 218.5 passing yards per game.

Joe Fagnano led the Huskies with 285/413 completed passes and 3,448 total passing yards, throwing 28 touchdowns and 10 interceptions. Camryn Edwards led the team in rushing yards with 1,240, adding a team-high 15 rushing touchdowns, while Skyler Bell had a team-high 101 caught passes for 1,278 receiving yards and 13 receiving touchdowns. Defensively, Bryun Parham led the team with 126 total tackles (63 solo), while Donovan Branch led UConn in sacks with 3.5.

Lafayette Leopards Preview


Lafayette finished last season with an 8-4 overall record, a 6-1 conference record, and were 2nd in the Patriot League. Offensively, the Leopards scored 33.6 points per game last season. Defensively, they allowed 28.7 points per game. Lafayette averaged 422.5 total yards per game last season, with 205.2 average rushing yards and 217.3 average passing yards per game. They allowed 385 total yards per game, 149.1 of them rushing and 235.9 passing yards per game.

Dean DeNobile led the Leopards with 223/347 completed passes and 2,528 total passing yards and had 19 touchdowns and 10 interceptions. Kente Edwards led the team in rushing yards, with 1,454, adding a team-high 20 rushing touchdowns, while Carson Persing had a team-high 60 caught passes with 724 receiving yards and 4 receiving touchdowns. Defensively, Ryan Gadson had a team-high 67 total tackles, 53 of them solo, while Jaylon Joseph led Lafayette in sacks, with 7.5.

Lafayette Leopards @ Connecticut Huskies Betting Trends: Week 1


Why the Connecticut Huskies will win

Why the Lafayette Leopards will win

Total Points Facts

Connecticut Huskies Player Prop Facts

Matchup/League Facts

Lafayette vs UConn Prediction


In this Lafayette vs UConn Prediction, UConn is coming as -19.5 home favorites. Both teams were very efficient offensively last season, with UConn having a top-15 offense in the country and both teams scoring 68.9 points per game combined. The Huskies were 9-4 to the over last season and I don’t expect them to switch to a defensive-minded approach in their season opener in front of their home crowd. I like points in this one, so take the over 52.5 today.

Nikos Lagouretos's Pick: Over 52.5

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