Kentucky (2-1) vs South Carolina (2-2)
September 27, 2025 at 07:45 PM EDT
The Line: Betting Odds: South Carolina -5.5 — Over/Under: +45.5
The Kentucky Wildcats and South Carolina Gamecocks meet Saturday in college football action at Williams-Brice Stadium. Here’s a Kentucky vs South Carolina Prediction. This article will include a Kentucky vs South Carolina Pick.
The Kentucky Wildcats beat Eastern Michigan, lost to Ole Miss, and they play Georgia next. Kentucky has split its last 6 games. Cutter Boley is completing 54.2 percent of his passes for 278 yards, 2 touchdowns, and 0 interceptions. Josh Kattus and Ja’Mori Maclin have combined for 215 receiving yards and 1 touchdown, while Hardley Gilmore IV has 6 receptions.
The Kentucky Wildcats ground game is averaging 214.7 yards per contest, and Seth McGowan leads the way with 275 yards and 6 touchdowns. Defensively, Kentucky is allowing 23 points and 415 yards per game. Alex Afari Jr. leads the Kentucky Wildcats with 26 tackles, Steven Soles Jr. has 2 sacks and Ty Bryant has 2 interceptions.
The South Carolina Gamecocks lost to Vanderbilt and Missouri, and will play LSU next. The South Carolina Gamecocks have lost 3 of their last 5 games. LaNorris Sellers is completing 64.4 percent of his passes for 733 yards, 4 touchdowns, and 1 interception. Vandrevius Jacobs and Nyck Harbor have combined for 425 receiving yards and 3 touchdowns, while Donovan Murph has 5 receptions.
The South Carolina Gamecocks ground game is averaging 80.3 yards per contest, and Rahsul Faison leads the way with 140 yards and 1 touchdown. Defensively, South Carolina is allowing 20.3 points and 346.3 yards per game. Fred Johnson leads the South Carolina Gamecocks with 20 tackles, Dylan Stewart has 2 sacks and Peyton Williams has 1 interception.
Kentucky is a well coached team that’s worth looking at in the underdog role, but they haven’t played on the road yet and have struggled defensively. South Carolina is due for a bounce back game, and a quarterback like Sellers could take advantage of a Kentucky defense that’s 116th in total defense and 125th against the pass. Kentucky has covered its last four games as a road dog, but its limitations up to this point have me questioning if it can keep up. After two disappointing showings, this feels like a spot where South Carolina gets back on track, at least offensively. We’re laying less than a touchdown, I’ll roll with the Gamecocks at home.
Kentucky Wildcats Betting Preview
The Kentucky Wildcats beat Eastern Michigan, lost to Ole Miss, and they play Georgia next. Kentucky has split its last 6 games. Cutter Boley is completing 54.2 percent of his passes for 278 yards, 2 touchdowns, and 0 interceptions. Josh Kattus and Ja’Mori Maclin have combined for 215 receiving yards and 1 touchdown, while Hardley Gilmore IV has 6 receptions.
The Kentucky Wildcats ground game is averaging 214.7 yards per contest, and Seth McGowan leads the way with 275 yards and 6 touchdowns. Defensively, Kentucky is allowing 23 points and 415 yards per game. Alex Afari Jr. leads the Kentucky Wildcats with 26 tackles, Steven Soles Jr. has 2 sacks and Ty Bryant has 2 interceptions.
South Carolina Gamecocks Betting Preview
The South Carolina Gamecocks lost to Vanderbilt and Missouri, and will play LSU next. The South Carolina Gamecocks have lost 3 of their last 5 games. LaNorris Sellers is completing 64.4 percent of his passes for 733 yards, 4 touchdowns, and 1 interception. Vandrevius Jacobs and Nyck Harbor have combined for 425 receiving yards and 3 touchdowns, while Donovan Murph has 5 receptions.
The South Carolina Gamecocks ground game is averaging 80.3 yards per contest, and Rahsul Faison leads the way with 140 yards and 1 touchdown. Defensively, South Carolina is allowing 20.3 points and 346.3 yards per game. Fred Johnson leads the South Carolina Gamecocks with 20 tackles, Dylan Stewart has 2 sacks and Peyton Williams has 1 interception.
Kentucky Wildcats @ South Carolina Gamecocks Betting Trends: Week 5
Why the South Carolina Gamecocks will win
- Kentucky has lost 10 of its last 11 games against conference opponents.
- South Carolina has won seven of its last eight games against non-AP-ranked teams.
- Kentucky has failed to cover the spread in four of its last five September games as an underdog against non-AP-ranked teams.
- The favorite has covered the spread in each of Kentucky’s last three games at Williams-Brice Stadium.
Why the Kentucky Wildcats will win
- Kentucky has won each of its last four road openers.
- Kentucky has covered the spread in each of its last four games as a road underdog.
- South Carolina has failed to cover the spread in three of its last four games as a favorite.
Total Points Facts
- Nine of the last 10 games between Kentucky and South Carolina have gone UNDER the total points line.
- Nine of Kentucky’s last 10 road games in September have gone UNDER the total points line.
South Carolina Gamecocks Player Prop Facts
- Heading into Week 5, Vandrevius Jacobs leads South Carolina for receptions (13) this season.
Kentucky Wildcats Player Prop Facts
- Heading into Week 5, Steven Soles Jr. leads the Southeastern Conference for forced fumbles (2) this season.
Matchup/League Facts
- South Carolina ranks T125th among FBS teams for 3rd down conversion percentage this season (29.8).
- South Carolina ranks T122nd among FBS teams for yards per game this season (300.5).
- Kentucky ranks 123rd among FBS teams for Q2 opponent points per game this season (10.7).
- Kentucky ranks T17th among FBS teams for average point differential in first quarters this season (+8.3).
Kentucky vs South Carolina Prediction
Kentucky is a well coached team that’s worth looking at in the underdog role, but they haven’t played on the road yet and have struggled defensively. South Carolina is due for a bounce back game, and a quarterback like Sellers could take advantage of a Kentucky defense that’s 116th in total defense and 125th against the pass. Kentucky has covered its last four games as a road dog, but its limitations up to this point have me questioning if it can keep up. After two disappointing showings, this feels like a spot where South Carolina gets back on track, at least offensively. We’re laying less than a touchdown, I’ll roll with the Gamecocks at home.