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Kansas State vs Arizona Prediction 9/12/2025 Today’s College Football Picks

Sep 6, 2025; Manhattan, Kansas, USA; Kansas State Wildcats quarterback Avery Johnson (2) looks for room to run during the third quarter against the Army Black Knights at Bill Snyder Family Football Stadium. Mandatory Credit: Scott Sewell-Imagn Images

Sep 6, 2025; Manhattan, Kansas, USA; Kansas State Wildcats quarterback Avery Johnson (2) looks for room to run during the third quarter against the Army Black Knights at Bill Snyder Family Football Stadium. Mandatory Credit: Scott Sewell-Imagn Images

Kansas State (1-2) vs Arizona (2-0)

September 12, 2025 at 09:00 PM EDT

The Line: Betting Odds: Arizona +2.5 — Over/Under: +54.5

(Get latest betting odds)

In this article we will formulate a Kansas State vs Arizona prediction for this College Football game on Friday, September 12th at Arizona Stadium in Tucson, Arizona. Let’s take a look at the prediction for this week 3 matchup. 

Kansas State Wildcats Betting Preview

The Kansas State Wildcats are 1-2 (0-1) this year after they lost to Army by a score of 24-21 last week. Kansas State led 13-0 late in the second quarter and 21-14 in the third, but they were outscored 10-0 in the fourth for the loss. The Wildcats were out gained by a total of 332-246, went 2-9 on third down, and lost the turnover battle by a margin of 1-0. Avery Johnson went 15-25 for 172 yards, one touchdown, and one interception in the game. Joe Jackson rushed seven times for 30 yards, while Jaron Tibbs caught five passes for 61 yards and one score. 

Kansas State lost against Iowa State in week zero by a score of 24-21, but they did beat North Dakota by a score of 38-35 in week one. Kansas State is scoring 28.7 points per game and they are allowing 27.7 points against per game on defense. The Wildcats are averaging 254.3 passing yards and 109 rushing yards per game this season. Avery Johnson has completed 65.3% of his passes for 763 yards, six touchdowns, and one interception for K-State this year. Joe Jackson has rushed for 136 yards, while Jayce Brown has caught 19 passes for 216 yards and two scores this season. 

Arizona Wildcats Betting Preview

The Arizona Wildcats are 2-0 (0-0) this season after they defeated Weber State by a score of 48-3 in their last game. Arizona led 24-0 after the first quarter and 34-0 at the half, before cruising to the win in the second half. The Wildcats out gained Weber State by a total of 556-184, went 5-10 on third downs, and won the turnover battle by a margin of 2-0 in the victory. Noah Fifita went 17-22 for 373 yards and five touchdowns, while Ismail Mahdi rushed nine times for 51 yards in the game. Javin Whatley led the receivers with five catches for 168 yards and two scores. 

Arizona started the season with a win over Hawaii by a score of 40-6 in week one. The Wildcats are scoring 44 points per game, while they are allowing 4.5 points against per game on defense. Arizona is averaging 283.5 passing yards per game and 166.5 rushing yards per game on offense this year. Noah Fifita has completed 66.7% of his passes for 534 yards and six touchdowns this season, while Quincy Craig has rushed for 156 yards and one score. Javin Whatley has caught eight passes for 206 yards and two touchdowns, while Luke Wysong has caught four passes for 70 yards this year. 

Why Arizona will beat Kansas State

Kansas State has lost three of its last four September games as a road favorite against non-AP-ranked teams.
Arizona has won each of its last four September games against non-AP-ranked teams.
Kansas State has failed to cover the spread in seven of its last eight road games.
The home team has covered the spread in five of Arizona’s last six games.

Total Points Facts

Each of Arizona’s last six September games against non-AP-ranked teams have gone UNDER the total points line.
Five of Kansas State’s last six games against conference opponents have gone UNDER the total points line.

Matchup/League Facts

Arizona ranks T2nd among FBS teams for average point differential in third quarters this season (+14.0).
Arizona ranks 3rd among FBS teams for interceptions this season (5).
Kansas State ranks 133rd among FBS teams for 1st downs against this season (62).
Kansas State ranks 127th among FBS teams for time of possession per game this season (24:49).

David Racey is 20-15 (57%) in College Football this season. Click here for his premium plays for this week!

Kansas State vs Arizona Prediction 

Kansas State comes into this matchup as one of the most disappointing teams to start this season, so they could really use a victory here. K-State battled hard against Iowa State to start the year, but they were lucky to get by North Dakota and lost to Army. Arizona dominated Hawaii and Weber State in their first two games, but this is a big step up in competition here. We are going to find out a lot about Kansas State in this game, but I don’t see any reason to trust them after seeing their last two games. Take Arizona to cover at home.

David Racey's Pick: Arizona +2.5

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