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Iowa vs USC Prediction 11/15/2025 Today’s College Football Picks

Nov 7, 2025; Los Angeles, California, USA; Southern California Trojans running back King Miller (30) runs the ball against the Northwestern Wildcats during the second half at the Los Angeles Memorial Coliseum. Mandatory Credit: Gary A. Vasquez-Imagn Images

Nov 7, 2025; Los Angeles, California, USA; Southern California Trojans running back King Miller (30) runs the ball against the Northwestern Wildcats during the second half at the Los Angeles Memorial Coliseum. Mandatory Credit: Gary A. Vasquez-Imagn Images

MATCHUP Hawkeyes Iowa Trojans USC
Team Records 6-3 7-2
Spread +7 -112 -7 -108
Moneyline +205 -250
Total Over 49.5 (-110) Under 49.5 (-110)
Where Los Angeles Memorial Coliseum, Los Angeles, CA
When Saturday, November 15, 2025
Time 03:30 PM EST
TV BTN
The Iowa Hawkeyes and USC Trojans meet Saturday in college football action at Los Angeles Memorial Coliseum. Here’s a Iowa vs USC Prediction. This article will include a Iowa vs USC Pick.

Iowa Hawkeyes Betting Preview


The Iowa Hawkeyes beat Minnesota, lost to Oregon, and they play Michigan State next. The Iowa Hawkeyes have won 3 of their last 4 games. Mark Gronowski is completing 63.9 percent of his passes for 1,084 yards, 5 touchdowns, and 4 interceptions. Jacob Gill and Sam Phillips have combined for 409 receiving yards on 30 catches, while Kaden Wetjen has 17 receptions.

The Iowa Hawkeyes ground game is averaging 175.9 yards per contest, and Kamari Moulton leads the way with 522 yards and 2 touchdowns. Defensively, Iowa is allowing 13.7 points and 250.2 yards per game. Karson Sharar leads the Iowa Hawkeyes with 56 tackles, Max Liewellyn has 6 sacks and Zach Lutmer has 2 interceptions.

USC Trojans Betting Preview


The USC Trojans beat Nebraska and Northwestern, and they play Oregon next. The USC Trojans have won 8 of their last 10 games. Jayden Maiava is completing 66.2 percent of his passes for 2,614 yards, 17 touchdowns and 6 interceptions. Makai Lemon and Ja’Kobi Lane have combined for 1,457 receiving yards and 11 touchdowns, while Lake McRee has 21 receptions.

The USC Trojans ground game is averaging 200.2 yards per contest, and King Miller leads the way with 636 yards and 5 touchdowns. Defensively, USC is allowing 21.8 points and 346.8 yards per game. Eric Gentry leads the USC Trojans with 61 tackles, Braylan Shelby has 3.5 sacks and Bishop Fitzgerald has 5 interceptions.

Why the USC Trojans will win

Why the Iowa Hawkeyes will win

Total Points Facts

USC Trojans Player Prop Facts

Iowa Hawkeyes Player Prop Facts

Matchup/League Facts

Iowa vs USC Prediction


USC is the more talented team and has the explosive offense to pull away. If Iowa gets down a couple of scores early, I’ll be afraid due to a passing attack that’s nonexistent. However, we’re getting a full touchdown with an Iowa defense that’s one of the best in the country. Iowa was getting owned in the trenches last week against Oregon, but still allowed just 16 points and had a chance to win late. It’s not pretty, but Iowa is still a tough-minded team that doesn’t get blown out often. Iowa’s three losses this season have been decided by an average of 3.33 points. Give me the free touchdown with the Hawkeyes.

Randy Chambers's Pick: Iowa +7

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