Indiana vs Penn State Prediction 11/8/2025 Today’s College Football Picks
Chris Ruffolo
Nov 1, 2025; College Park, Maryland, USA;
Indiana Hoosiers quarterback Fernando Mendoza (15) rushes during the first half against the Maryland Terrapins at SECU Stadium. Mandatory Credit: Tommy Gilligan-Imagn Images
MATCHUP
Hoosiers Indiana
Nittany Lions Penn State
Team Records
9-0
3-5
Spread
-14.5 -108
+14.5 -112
Moneyline
-625
+455
Total
Over 49.5 (-112)
Under 49.5 (-108)
Where
Beaver Stadium, University Park, PA
When
Saturday, November 8, 2025
Time
12:00 PM EST
TV
FOX
The Indiana Hoosiers and the Penn State Nittany Lions meet in week 11 college football action from Beaver Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Indiana Hoosiers vs. Penn State Nittany Lions prediction.
Indiana Hoosiers Recap
The Indiana Hoosiers come into this game looking to build on their 55-10 win over Maryland last time out to sit at 9-0 this season. After this game, Indiana will head home for a game against Wisconsin.
Hoosiers Looking To Stay Undefeated
Fernando Mendoza leads Indiana in passing with 2,124 yards, 25 touchdowns and 4 interceptions on 72.3% passing while Kaelon Black has a team-high 619 rushing yards and 4 touchdowns and Roman Hembu has 601 receiving yards as well this season. Khobie Martin has also added 368 rushing yard and 5 touchdowns. Omar Cooper Jr. has a team-high 46 catches for 669 yards and 8 touchdowns while Elijah Sarratt has 45 grabs for 609 yards and 10 touchdowns this season. E.J. Williams Jr. also has 336 receiving yards and 5 TDs. On defense, Louis Moore has a team-high 57 total tackles along with 5 interceptions while Isaiah Jones and Rolijah Hardy each have a team-high 5 sacks. Amare Ferrell also has 3 interceptions and Tyrique Tucker has 4.5 sacks as well this season. As a unit, Indiana’s defense has combined for 29 sacks and 13 interceptions so far this season.
Penn State Nittany Lions Recap
The Penn State Nittany Lions come into this game looking to bounce back from a 38-14 loss at the hands of Ohio State last time out to sit at 3-5 this season. After this game, Penn State will head on the road for a game against Michigan State.
Nittany Lions Drop 5th In A Row
Drew Allar has thrown for 1,100 yards, 8 touchdowns and 3 interceptions on 64.8% passing while Ethan Grunkemeyer has 343 passing yards, a touchdown and 3 interceptions on 62.7% passing. Kaytron Allen leads Penn State with 688 rushing yards and 10 touchdowns while Nicholas Singleton has 292 rushing yards and 7 touchdowns. Devonte Ross has a team-high 23 catches for 281 yards and 3 touchdowns while Kyron Hudson has 20 grabs for 236 yards and 2 TDs and Trebor Pena has a team-high 26 catches for 232 yards. Luke Reynolds have 213 receiving yards and another pair of receivers have 100+ receiving yards as well on the year. On defense, Amare Campbell has a team-high 59 total tackles along with a pair of sacks while Penn State as a team has combined for 14 sacks and 5 interceptions this season.
Indiana Hoosiers @ Penn State Nittany Lions Betting Trends: Week 11
Why the Penn State Nittany Lions will win
Penn State has won nine of its last 10 games against Indiana.
The underdog has covered the spread in eight of Penn State’s last nine games.
The team ranked 2nd in the AP Poll has failed to cover the spread in six of its last eight games.
Penn State has won the first half in 13 of its last 17 home games against conference opponents.
Why the Indiana Hoosiers will win
Indiana has won each of its last 18 games against non-AP-ranked teams.
Penn State has lost each of its last 11 November games against top-15 AP-ranked teams.
Penn State has failed to cover the spread in 12 of its last 13 November games against AP-ranked teams.
Indiana has covered the spread in each of its last five November road games against non-AP-ranked teams.
Indiana has won the first quarter in each of its last nine games against conference opponents.
Indiana has won the first half in 14 of its last 16 games against conference opponents.
Total Points Facts
Each of Indiana’s last eight road games in November have gone OVER the total points line.
Eight of Penn State’s last nine games against conference opponents have gone OVER the total points line.
Penn State Nittany Lions Player Prop Facts
Heading into Week 11, Kaytron Allen ranks T13th amongst FBS players for rushing touchdowns (10) this season.
Indiana Hoosiers Player Prop Facts
Heading into Week 11, Louis Moore ranks T1st amongst FBS players for interceptions (5) this season.
Matchup/League Facts
Penn State ranks T7th among FBS teams for Q4 points per game this season (10.3).
Penn State ranks 14th among FBS teams for passing yards allowed per game this season (166.4).
Indiana ranks 1st among FBS teams for points per game this season (46.4).
Indiana has recorded the most home wins by a margin of 10+ points of any FBS team this season (6).
Indiana Hoosiers vs. Penn State Nittany Lions Prediction
I’m on the Hoosiers here. I get the case to be made for Penn State as an underdog if they were better from a record perspective than they are this year, but a lot has gone wrong for Penn State and I honestly think it’s going to get worse before it gets better. Indiana has been playing some solid football all season and Curt Cignetti isn’t the kind of coach to take his foot off of the gas. This may be Penn State’s super bowl, at home against the #2 team in the country, but nothing is helping Penn State in this matchup. Give me the Hoosiers big.
