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Indiana vs Ohio State Prediction 12/6/2025 Today’s College Football Picks

Ohio State Buckeyes quarterback Julian Sayin (10) takes a snap from offensive lineman Carson Hinzman (75) during the NCAA football game against the Michigan Wolverines at Michigan Stadium in Ann Arbor, Mich. on Nov. 29, 2025. Ohio State won 27-9.

Ohio State Buckeyes quarterback Julian Sayin (10) takes a snap from offensive lineman Carson Hinzman (75) during the NCAA football game against the Michigan Wolverines at Michigan Stadium in Ann Arbor, Mich. on Nov. 29, 2025. Ohio State won 27-9.

MATCHUP Indiana Hoosiers Ohio State Buckeyes
Team Records 12-0 12-0
Spread +4.5 -108 -4.5 -112
Moneyline +170 -205
Total Over 48.5 (-105) Under 48.5 (-115)
When Saturday, December 6, 2025
Time 08:00 PM EST
TV FOX
In this article, we will formulate an Indiana vs Ohio State Prediction for this College Football Big Ten Championship game on Saturday, December 6th. Let’s take a look at the prediction for this College Football matchup.

Ohio State Buckeyes Preview


Ohio State has a 12-0 record this season and finished 1st in the Big Ten. They are coming off a 27-9 road win against Michigan. Offensively, Ohio State averages 37 points per game, ranking 13th in the nation, while defensively, they allow 7.8 points per game, which is 1st. Ohio State averages 438.5 total yards per game (267 passing and 171.5 rushing), while allowing 203 total yards per game (81.7 rushing and 121.3 passing).

Julian Sayin leads Ohio State with 3,065 passing yards with 78.9% completed passes and 30 touchdowns. Bo Jackson leads the team in rushing yards with 952, while Jeremiah Smith has a team-high 72 receptions for 942 receiving yards. Defensively, Sonny Styles has a team-high 68 total tackles (38 of them solo), while Caden Curry leads the team in sacks, with 9, and Caleb Downs, Jermaine Matthews Jr. and Payton Pierce lead the team with 2 interceptions each.

Indiana Hoosiers Preview


Indiana has a 12-0 record this season and finished 1st in the Big Ten. They are coming off a 56-3 road win against Purdue. Offensively, Indiana averages 44.3 points per game, ranking 2nd in the nation, while defensively, they allow 10.9 points per game, which is 2nd. Indiana averages 483.8 total yards per game (254.1 passing and 229.8 rushing), while allowing 251.8 total yards per game (79.3 rushing and 172.5 passing).

Fernando Mendoza leads Indiana with 2,758 passing yards with 72% completed passes and 32 touchdowns. Roman Hemby leads the team in rushing yards with 866, while Omar Cooper Jr. has a team-high 58 receptions for 804 receiving yards. Defensively, Rolijah Hardy has a team-high 76 total tackles (35 of them solo), while Stephen Daley leads the team in sacks, with 4.5, and Louis Moore has a team-high 5 interceptions.

Indiana Hoosiers @ Ohio State Buckeyes Betting Trends: Conference Championships


Why the Ohio State Buckeyes will win

Why the Indiana Hoosiers will win

Total Points Facts

Ohio State Buckeyes Player Prop Facts

Indiana Hoosiers Player Prop Facts

Matchup/League Facts

Indiana vs Ohio State Prediction


In this Indiana vs Ohio State Prediction, Ohio State is coming as -4.5-point home favorites. Both teams were excellent in the regular season, as they both finished their campaigns undefeated. Ohio State was almost perfect against the spread with a 10-1 record, while Indiana was 7-5 against the spread. Indiana has the second-best offense in the whole country, but those two teams are the best in the nation defensively, holding their opponents into just 17.8 points per game combined. With this being a playoff game, I expect an extremely tight game between the two best defenses of the country, so go under the 48 points in this one.

Nikos Lagouretos's Pick: Under 48

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